Unveiling the Biological Properties of <i>Rosa rubiginosa</i> L. Leaf Extract as a Bio-Functional Ingredient Based on 2D Cell-Based Models and In Vitro Assessments
Natural ingredients have long been utilized to enhance human health. While <i>Rosa rubiginosa</i> L. has been relatively understudied, it is known for its antioxidant and anti-inflammatory properties. This study explores its diverse bioactivity on human primary keratinocytes and fibrobla...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
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| Series: | Cosmetics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-9284/12/2/62 |
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| Summary: | Natural ingredients have long been utilized to enhance human health. While <i>Rosa rubiginosa</i> L. has been relatively understudied, it is known for its antioxidant and anti-inflammatory properties. This study explores its diverse bioactivity on human primary keratinocytes and fibroblasts, highlighting its potential as a bio-functional agent in cosmeceuticals or nutraceuticals. The <i>Rosa rubiginosa</i> L. leaf extract demonstrated strong scavenging activity and high phenolic content protection while also preventing DNA breakage. At the molecular level, ATP determination revealed that the <i>Rosa rubiginosa</i> L. leaf confers cell viability even under oxidative stress. Gene expression analysis uncovered its protective effects on human primary keratinocytes and fibroblasts due to its strong antioxidant and anti-inflammatory response under oxidative stress induced by UVA irradiation. These findings suggest that <i>Rosa rubiginosa</i> L. leaf extract provides significant in vitro biological properties in cell-based models, offering new insights into its potential benefits and underscoring its bio-functional role. |
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| ISSN: | 2079-9284 |