Molecular targets for metastasis-directed therapy in malignant tumors
Over the past two decades, targeted therapy has actively developed and, demonstrating impressive clinical results, has gained an increasingly important role in the treatment of cancer. This was facilitated to a large extent by an in-depth understanding of the mechanisms of cancer development, and ma...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2024-07-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/5667 |
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| author | V. V. Bodenko M. S. Larkina A. A. Prach E. V. Plotnikov M. V. Belousov V. I. Chernov |
| author_facet | V. V. Bodenko M. S. Larkina A. A. Prach E. V. Plotnikov M. V. Belousov V. I. Chernov |
| author_sort | V. V. Bodenko |
| collection | DOAJ |
| description | Over the past two decades, targeted therapy has actively developed and, demonstrating impressive clinical results, has gained an increasingly important role in the treatment of cancer. This was facilitated to a large extent by an in-depth understanding of the mechanisms of cancer development, and mainly, the discovery of molecular targets. Despite the fact that targeted therapy can radically change the results of treatment and the prognosis of the disease course in some cancer cases, its effectiveness is sometimes replaced by drug resistance, in others. The authors of the lecture analyzed and systematized therapeutic approaches to addressing a number of important molecular targets that are key for implementing a specific stage in human tumor pathogenesis. These include maintaining chronic proliferative signaling, promoting evasion of cell growth suppressors, inducing angiogenesis, forming immune surveillance, and activating invasion and metastasis. The lecture presented targeted therapy drugs used in the Russian Federation, including antibody-based drugs and small molecule tyrosine kinase inhibitors. It also analyzed mechanisms of molecular interaction between these drugs and their targets, as well as possible factors for developing resistance and ways to overcome these resistance mechanisms. |
| format | Article |
| id | doaj-art-6fcf56c250b747afa527e20f1fdbf1ad |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-6fcf56c250b747afa527e20f1fdbf1ad2025-08-20T04:00:12ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842024-07-0123210111310.20538/1682-0363-2024-2-101-1133077Molecular targets for metastasis-directed therapy in malignant tumorsV. V. Bodenko0M. S. Larkina1A. A. Prach2E. V. Plotnikov3M. V. Belousov4V. I. Chernov5Siberian State Medical University; National Research Tomsk Polytechnic UniversitySiberian State Medical UniversityNational Research Tomsk Polytechnic UniversityNational Research Tomsk Polytechnic UniversitySiberian State Medical UniversityCancer Research Institute, Tomsk National Research Medical Center (NRMC), Russian Academy of SciencesOver the past two decades, targeted therapy has actively developed and, demonstrating impressive clinical results, has gained an increasingly important role in the treatment of cancer. This was facilitated to a large extent by an in-depth understanding of the mechanisms of cancer development, and mainly, the discovery of molecular targets. Despite the fact that targeted therapy can radically change the results of treatment and the prognosis of the disease course in some cancer cases, its effectiveness is sometimes replaced by drug resistance, in others. The authors of the lecture analyzed and systematized therapeutic approaches to addressing a number of important molecular targets that are key for implementing a specific stage in human tumor pathogenesis. These include maintaining chronic proliferative signaling, promoting evasion of cell growth suppressors, inducing angiogenesis, forming immune surveillance, and activating invasion and metastasis. The lecture presented targeted therapy drugs used in the Russian Federation, including antibody-based drugs and small molecule tyrosine kinase inhibitors. It also analyzed mechanisms of molecular interaction between these drugs and their targets, as well as possible factors for developing resistance and ways to overcome these resistance mechanisms.https://bulletin.ssmu.ru/jour/article/view/5667egfrher2vegfbcr-abl1cdk4/6ctla-4pd-1c-мet |
| spellingShingle | V. V. Bodenko M. S. Larkina A. A. Prach E. V. Plotnikov M. V. Belousov V. I. Chernov Molecular targets for metastasis-directed therapy in malignant tumors Бюллетень сибирской медицины egfr her2 vegf bcr-abl1 cdk4/6 ctla-4 pd-1 c-мet |
| title | Molecular targets for metastasis-directed therapy in malignant tumors |
| title_full | Molecular targets for metastasis-directed therapy in malignant tumors |
| title_fullStr | Molecular targets for metastasis-directed therapy in malignant tumors |
| title_full_unstemmed | Molecular targets for metastasis-directed therapy in malignant tumors |
| title_short | Molecular targets for metastasis-directed therapy in malignant tumors |
| title_sort | molecular targets for metastasis directed therapy in malignant tumors |
| topic | egfr her2 vegf bcr-abl1 cdk4/6 ctla-4 pd-1 c-мet |
| url | https://bulletin.ssmu.ru/jour/article/view/5667 |
| work_keys_str_mv | AT vvbodenko moleculartargetsformetastasisdirectedtherapyinmalignanttumors AT mslarkina moleculartargetsformetastasisdirectedtherapyinmalignanttumors AT aaprach moleculartargetsformetastasisdirectedtherapyinmalignanttumors AT evplotnikov moleculartargetsformetastasisdirectedtherapyinmalignanttumors AT mvbelousov moleculartargetsformetastasisdirectedtherapyinmalignanttumors AT vichernov moleculartargetsformetastasisdirectedtherapyinmalignanttumors |