Conditional knockout of C/EBPβ in epidermis results in dysregulated lipid biosynthesis and a defect in skin barrier function.

Conditional knockout of C/EBPβ in epidermis results in dysregulated lipid biosynthesis and a defect in skin barrier function.

CCAAT/enhancer binding protein-β (C/EBPβ) is a basic leucine zipper transcription factor that is abundantly expressed in epidermal keratinocytes of skin. In the present study, C/EBPβ epidermal specific conditional knockout (CKOβ) SKH1 mice were utilized to interrogate C/EBPβ's role in lipid bio...

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Bibliographic Details
Main Authors: Kevin J Mills, Michael Doyle, John S House, John G Witherspoon, Daniel Krakko, Whitney L Stutts, Jessie R Chappel, Jonathan R Hall, Erin S Baker, Robert C Smart
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0326670
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