Genetic evidence for a protective role of Omega-3 fatty acids in nummular dermatitis
Background: The causal relationship between Omega-3 fatty acids and nummular dermatitis remains unclear.Methods: We performed a two-sample Mendelian randomization analysis using six independent SNPs associated with circulating Omega-3 levels. Summary statistics for nummular dermatitis were obtained...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Food and Agricultural Immunology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09540105.2025.2529306 |
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| author | Yi Chen Zhimin Wu Lucy Yue Lau Boyang Li Yipeng Pan Alice Yang Yuanyuan Zhang Chao Shu Yifei Ma Hongyi Zhang Wenjia Guo |
| author_facet | Yi Chen Zhimin Wu Lucy Yue Lau Boyang Li Yipeng Pan Alice Yang Yuanyuan Zhang Chao Shu Yifei Ma Hongyi Zhang Wenjia Guo |
| author_sort | Yi Chen |
| collection | DOAJ |
| description | Background: The causal relationship between Omega-3 fatty acids and nummular dermatitis remains unclear.Methods: We performed a two-sample Mendelian randomization analysis using six independent SNPs associated with circulating Omega-3 levels. Summary statistics for nummular dermatitis were obtained from the FinnGen consortium. The inverse variance weighted method was the primary analysis, complemented by MR-Egger, weighted median, and mode-based approaches. Sensitivity analyses assessed pleiotropy and heterogeneity.Results: Higher genetically predicted Omega-3 levels were significantly associated with a reduced risk of nummular dermatitis (β = −0.25, 95% CI: – 0.45 to – 0.06, P = 0.0111). The association was consistent across multiple MR methods, with no evidence of horizontal pleiotropy or significant heterogeneity.Conclusion: This study provides the first genetic evidence supporting a protective causal effect of Omega-3 fatty acids against nummular dermatitis, highlighting the potential of nutritional interventions for inflammatory skin diseases. |
| format | Article |
| id | doaj-art-6fcd4e0ce28543ec98d5c8e6fde67981 |
| institution | Kabale University |
| issn | 0954-0105 1465-3443 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Food and Agricultural Immunology |
| spelling | doaj-art-6fcd4e0ce28543ec98d5c8e6fde679812025-08-20T03:43:58ZengTaylor & Francis GroupFood and Agricultural Immunology0954-01051465-34432025-12-0136110.1080/09540105.2025.2529306Genetic evidence for a protective role of Omega-3 fatty acids in nummular dermatitisYi Chen0Zhimin Wu1Lucy Yue Lau2Boyang Li3Yipeng Pan4Alice Yang5Yuanyuan Zhang6Chao Shu7Yifei Ma8Hongyi Zhang9Wenjia Guo10Cancer Research Institute, The Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, People’s Republic of ChinaThe Maternal and Child Health Care Hospital of Guizhou Medical University, Guiyang, People’s Republic of ChinaDepartment of Public health, Harvard Medical School, Boston, MA, USADepartment of Dermatology, The First Clinical School of Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of ChinaDepartment of Gastrointestinal Nutrition, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of ChinaDepartment of Dermatology, University College London Hospitals NHS Foundation Trust, London, UKHospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, People’s Republic of ChinaDepartment of Pathology, Midong District Hospital of Traditional Chinese Medicine, Urumqi, People’s Republic of ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of ChinaDepartment of Plastic Surgery, Hanghai East Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of ChinaCancer Research Institute, The Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, People’s Republic of ChinaBackground: The causal relationship between Omega-3 fatty acids and nummular dermatitis remains unclear.Methods: We performed a two-sample Mendelian randomization analysis using six independent SNPs associated with circulating Omega-3 levels. Summary statistics for nummular dermatitis were obtained from the FinnGen consortium. The inverse variance weighted method was the primary analysis, complemented by MR-Egger, weighted median, and mode-based approaches. Sensitivity analyses assessed pleiotropy and heterogeneity.Results: Higher genetically predicted Omega-3 levels were significantly associated with a reduced risk of nummular dermatitis (β = −0.25, 95% CI: – 0.45 to – 0.06, P = 0.0111). The association was consistent across multiple MR methods, with no evidence of horizontal pleiotropy or significant heterogeneity.Conclusion: This study provides the first genetic evidence supporting a protective causal effect of Omega-3 fatty acids against nummular dermatitis, highlighting the potential of nutritional interventions for inflammatory skin diseases.https://www.tandfonline.com/doi/10.1080/09540105.2025.2529306Omega-3 fatty acidsnummular dermatitisMendelian randomizationinflammatory skin diseasenutritional epidemiology |
| spellingShingle | Yi Chen Zhimin Wu Lucy Yue Lau Boyang Li Yipeng Pan Alice Yang Yuanyuan Zhang Chao Shu Yifei Ma Hongyi Zhang Wenjia Guo Genetic evidence for a protective role of Omega-3 fatty acids in nummular dermatitis Food and Agricultural Immunology Omega-3 fatty acids nummular dermatitis Mendelian randomization inflammatory skin disease nutritional epidemiology |
| title | Genetic evidence for a protective role of Omega-3 fatty acids in nummular dermatitis |
| title_full | Genetic evidence for a protective role of Omega-3 fatty acids in nummular dermatitis |
| title_fullStr | Genetic evidence for a protective role of Omega-3 fatty acids in nummular dermatitis |
| title_full_unstemmed | Genetic evidence for a protective role of Omega-3 fatty acids in nummular dermatitis |
| title_short | Genetic evidence for a protective role of Omega-3 fatty acids in nummular dermatitis |
| title_sort | genetic evidence for a protective role of omega 3 fatty acids in nummular dermatitis |
| topic | Omega-3 fatty acids nummular dermatitis Mendelian randomization inflammatory skin disease nutritional epidemiology |
| url | https://www.tandfonline.com/doi/10.1080/09540105.2025.2529306 |
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