Genetic evidence for a protective role of Omega-3 fatty acids in nummular dermatitis
Background: The causal relationship between Omega-3 fatty acids and nummular dermatitis remains unclear.Methods: We performed a two-sample Mendelian randomization analysis using six independent SNPs associated with circulating Omega-3 levels. Summary statistics for nummular dermatitis were obtained...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
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| Series: | Food and Agricultural Immunology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/09540105.2025.2529306 |
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| Summary: | Background: The causal relationship between Omega-3 fatty acids and nummular dermatitis remains unclear.Methods: We performed a two-sample Mendelian randomization analysis using six independent SNPs associated with circulating Omega-3 levels. Summary statistics for nummular dermatitis were obtained from the FinnGen consortium. The inverse variance weighted method was the primary analysis, complemented by MR-Egger, weighted median, and mode-based approaches. Sensitivity analyses assessed pleiotropy and heterogeneity.Results: Higher genetically predicted Omega-3 levels were significantly associated with a reduced risk of nummular dermatitis (β = −0.25, 95% CI: – 0.45 to – 0.06, P = 0.0111). The association was consistent across multiple MR methods, with no evidence of horizontal pleiotropy or significant heterogeneity.Conclusion: This study provides the first genetic evidence supporting a protective causal effect of Omega-3 fatty acids against nummular dermatitis, highlighting the potential of nutritional interventions for inflammatory skin diseases. |
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| ISSN: | 0954-0105 1465-3443 |