Pharmacotherapy of gout – modern approaches and prospects
The article discusses modern approaches to the gout treatment, presented in foreign and domestic clinical guidelines. While the use of urate-lowering therapy for gout is a necessary and highly effective strategy, in the case of asymptomatic hyperuricemia, the benefits of this approach are not clear....
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2021-08-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/1179 |
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| author | P. A. Lebedev A. A. Garanin N. L. Novichkova |
| author_facet | P. A. Lebedev A. A. Garanin N. L. Novichkova |
| author_sort | P. A. Lebedev |
| collection | DOAJ |
| description | The article discusses modern approaches to the gout treatment, presented in foreign and domestic clinical guidelines. While the use of urate-lowering therapy for gout is a necessary and highly effective strategy, in the case of asymptomatic hyperuricemia, the benefits of this approach are not clear. The safety and efficacy of colchicine, as well as its cardioprotective properties, were noted in comorbid patients suffering from gout and cardiovascular diseases. Comparative data on safety and efficacy of the main urate-lowering drugs, allopurinol and febuxostat, are presented. It has been shown that, according to recent studies, febuxostat is more effective than allopurinol in normalizing serum uric acid levels, is not inferior in its cardio safety and is characterized by a lower incidence of other adverse reactions. |
| format | Article |
| id | doaj-art-6fcbcb7ddc1c486db602a679994ba733 |
| institution | DOAJ |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2021-08-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-6fcbcb7ddc1c486db602a679994ba7332025-08-20T03:20:59ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2021-08-0115410711210.14412/1996-7012-2021-4-107-1122389Pharmacotherapy of gout – modern approaches and prospectsP. A. Lebedev0A. A. Garanin1N. L. Novichkova2Samara State Medical UniversitySamara State Medical UniversitySamara State Medical UniversityThe article discusses modern approaches to the gout treatment, presented in foreign and domestic clinical guidelines. While the use of urate-lowering therapy for gout is a necessary and highly effective strategy, in the case of asymptomatic hyperuricemia, the benefits of this approach are not clear. The safety and efficacy of colchicine, as well as its cardioprotective properties, were noted in comorbid patients suffering from gout and cardiovascular diseases. Comparative data on safety and efficacy of the main urate-lowering drugs, allopurinol and febuxostat, are presented. It has been shown that, according to recent studies, febuxostat is more effective than allopurinol in normalizing serum uric acid levels, is not inferior in its cardio safety and is characterized by a lower incidence of other adverse reactions.https://mrj.ima-press.net/mrj/article/view/1179goutcolchicinefebuxostatallopurinolhyperuricemiachronic kidney diseaserisk factorscardiovascular diseases |
| spellingShingle | P. A. Lebedev A. A. Garanin N. L. Novichkova Pharmacotherapy of gout – modern approaches and prospects Современная ревматология gout colchicine febuxostat allopurinol hyperuricemia chronic kidney disease risk factors cardiovascular diseases |
| title | Pharmacotherapy of gout – modern approaches and prospects |
| title_full | Pharmacotherapy of gout – modern approaches and prospects |
| title_fullStr | Pharmacotherapy of gout – modern approaches and prospects |
| title_full_unstemmed | Pharmacotherapy of gout – modern approaches and prospects |
| title_short | Pharmacotherapy of gout – modern approaches and prospects |
| title_sort | pharmacotherapy of gout modern approaches and prospects |
| topic | gout colchicine febuxostat allopurinol hyperuricemia chronic kidney disease risk factors cardiovascular diseases |
| url | https://mrj.ima-press.net/mrj/article/view/1179 |
| work_keys_str_mv | AT palebedev pharmacotherapyofgoutmodernapproachesandprospects AT aagaranin pharmacotherapyofgoutmodernapproachesandprospects AT nlnovichkova pharmacotherapyofgoutmodernapproachesandprospects |