Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus
Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimate...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/792393 |
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| _version_ | 1850222708318535680 |
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| author | Inge A. M. van den Oever Hennie G. Raterman Mike T. Nurmohamed Suat Simsek |
| author_facet | Inge A. M. van den Oever Hennie G. Raterman Mike T. Nurmohamed Suat Simsek |
| author_sort | Inge A. M. van den Oever |
| collection | DOAJ |
| description | Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabetes related complications. This review summarizes the mechanisms by which the interplay between endothelial dysfunction, inflammation, and apoptosis may cause (micro)vascular damage in patients with diabetes mellitus. |
| format | Article |
| id | doaj-art-6fc9090c9c7e495e8dc2ed69f2adb56b |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-6fc9090c9c7e495e8dc2ed69f2adb56b2025-08-20T02:06:15ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/792393792393Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes MellitusInge A. M. van den Oever0Hennie G. Raterman1Mike T. Nurmohamed2Suat Simsek3Department of Rheumatology, Jan van Breemen Institute, Amsterdam, The NetherlandsDepartment of Rheumatology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Rheumatology, Jan van Breemen Institute, Amsterdam, The NetherlandsDepartment of Internal Medicine, VU University Medical Center, Amsterdam, The NetherlandsEndothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabetes related complications. This review summarizes the mechanisms by which the interplay between endothelial dysfunction, inflammation, and apoptosis may cause (micro)vascular damage in patients with diabetes mellitus.http://dx.doi.org/10.1155/2010/792393 |
| spellingShingle | Inge A. M. van den Oever Hennie G. Raterman Mike T. Nurmohamed Suat Simsek Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus Mediators of Inflammation |
| title | Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus |
| title_full | Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus |
| title_fullStr | Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus |
| title_full_unstemmed | Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus |
| title_short | Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus |
| title_sort | endothelial dysfunction inflammation and apoptosis in diabetes mellitus |
| url | http://dx.doi.org/10.1155/2010/792393 |
| work_keys_str_mv | AT ingeamvandenoever endothelialdysfunctioninflammationandapoptosisindiabetesmellitus AT henniegraterman endothelialdysfunctioninflammationandapoptosisindiabetesmellitus AT miketnurmohamed endothelialdysfunctioninflammationandapoptosisindiabetesmellitus AT suatsimsek endothelialdysfunctioninflammationandapoptosisindiabetesmellitus |