Evaluation of Anti-psoriatic Activity of Aloe sinkatana Extract on Imiquimod Induced Psoriatic-like Dermatitis in Mice
Background: One of the most significant Sudanese medicinal plants is Aloe sinkatana, which has considerable pharmacological activity and has been historically used to treat psoriasis and other skin conditions. Objectives: This study aims to evaluate the A. sinkatana plant’s anti-psoriatic properties...
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Mazandaran University of Medical Sciences
2025-03-01
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| Series: | Pharmaceutical and Biomedical Research |
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| Online Access: | http://pbr.mazums.ac.ir/article-1-658-en.pdf |
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| author | Azza Dawoud Hussien Dawoud Mohammed Abdalbagi |
| author_facet | Azza Dawoud Hussien Dawoud Mohammed Abdalbagi |
| author_sort | Azza Dawoud Hussien Dawoud |
| collection | DOAJ |
| description | Background: One of the most significant Sudanese medicinal plants is Aloe sinkatana, which has considerable pharmacological activity and has been historically used to treat psoriasis and other skin conditions.
Objectives: This study aims to evaluate the A. sinkatana plant’s anti-psoriatic properties.
Methods: The imiquimod (IMQ)-induced psoriasis mice model was used to evaluate the anti-psoriatic effect of the A. sinkatana plant. So, the effects of 0.1% and 0.2% extracts of A. sinkatana extract on five groups of mice were assessed and compared with the conventional medication, i.e. dexamethasone. Differences between treatment groups were evaluated by a one-way analysis of variance, followed by a post hoc Fisher least significant difference test using the SPSS software, version 20. At P<0.05, differences were deemed significant. A minimum of three replicates were used in each duplicate experiment. For all values, Mean±SD was used.
Results: The extracts showed a significant and remarkably strong anti-psoriatic effect since the percentages of psoriasis-like symptoms were reduced in groups treated with 0.2% Aloe extract (A.E), 0.1% A.E, and dexamethasone 86%, 84%, and 68%, respectively. Both extract concentrations improved the psoriatic lesions and decreased the grading of the treated groups’ psoriasis area and severity index (PASI) scale.
Conclusion: Due to the constant research to develop a safe and effective topical preparation for the treatment of psoriasis, the current study provided an enhanced anti-psoriatic treatment, represented by A. sinkatana extract. This herb may be beneficial in the pharmaceutical formulation of new safe and effective medication for treating psoriasis. |
| format | Article |
| id | doaj-art-6fc1b443cfaa4773ba3c3aaa151eb47d |
| institution | OA Journals |
| issn | 2423-4494 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical and Biomedical Research |
| spelling | doaj-art-6fc1b443cfaa4773ba3c3aaa151eb47d2025-08-20T01:49:04ZengMazandaran University of Medical SciencesPharmaceutical and Biomedical Research2423-44942025-03-011114148Evaluation of Anti-psoriatic Activity of Aloe sinkatana Extract on Imiquimod Induced Psoriatic-like Dermatitis in MiceAzza Dawoud Hussien Dawoud0Mohammed Abdalbagi1 Department of Drug Formulation, Medicinal and Aromatic Plants & Traditional Medicine Research Institute, National Center of Research, Khartoum, Sudan. Department of Microbiology & Parasitology, Medicinal and Aromatic Plants & Traditional Medicine Research Institute, National Center of Research, Khartoum, Sudan. Background: One of the most significant Sudanese medicinal plants is Aloe sinkatana, which has considerable pharmacological activity and has been historically used to treat psoriasis and other skin conditions. Objectives: This study aims to evaluate the A. sinkatana plant’s anti-psoriatic properties. Methods: The imiquimod (IMQ)-induced psoriasis mice model was used to evaluate the anti-psoriatic effect of the A. sinkatana plant. So, the effects of 0.1% and 0.2% extracts of A. sinkatana extract on five groups of mice were assessed and compared with the conventional medication, i.e. dexamethasone. Differences between treatment groups were evaluated by a one-way analysis of variance, followed by a post hoc Fisher least significant difference test using the SPSS software, version 20. At P<0.05, differences were deemed significant. A minimum of three replicates were used in each duplicate experiment. For all values, Mean±SD was used. Results: The extracts showed a significant and remarkably strong anti-psoriatic effect since the percentages of psoriasis-like symptoms were reduced in groups treated with 0.2% Aloe extract (A.E), 0.1% A.E, and dexamethasone 86%, 84%, and 68%, respectively. Both extract concentrations improved the psoriatic lesions and decreased the grading of the treated groups’ psoriasis area and severity index (PASI) scale. Conclusion: Due to the constant research to develop a safe and effective topical preparation for the treatment of psoriasis, the current study provided an enhanced anti-psoriatic treatment, represented by A. sinkatana extract. This herb may be beneficial in the pharmaceutical formulation of new safe and effective medication for treating psoriasis.http://pbr.mazums.ac.ir/article-1-658-en.pdfaloe sinkatanadermatitisextractsimiquimod (imq)psoriasis area and severity index (pasi)mice |
| spellingShingle | Azza Dawoud Hussien Dawoud Mohammed Abdalbagi Evaluation of Anti-psoriatic Activity of Aloe sinkatana Extract on Imiquimod Induced Psoriatic-like Dermatitis in Mice Pharmaceutical and Biomedical Research aloe sinkatana dermatitis extracts imiquimod (imq) psoriasis area and severity index (pasi) mice |
| title | Evaluation of Anti-psoriatic Activity of Aloe sinkatana Extract on Imiquimod Induced Psoriatic-like Dermatitis in Mice |
| title_full | Evaluation of Anti-psoriatic Activity of Aloe sinkatana Extract on Imiquimod Induced Psoriatic-like Dermatitis in Mice |
| title_fullStr | Evaluation of Anti-psoriatic Activity of Aloe sinkatana Extract on Imiquimod Induced Psoriatic-like Dermatitis in Mice |
| title_full_unstemmed | Evaluation of Anti-psoriatic Activity of Aloe sinkatana Extract on Imiquimod Induced Psoriatic-like Dermatitis in Mice |
| title_short | Evaluation of Anti-psoriatic Activity of Aloe sinkatana Extract on Imiquimod Induced Psoriatic-like Dermatitis in Mice |
| title_sort | evaluation of anti psoriatic activity of aloe sinkatana extract on imiquimod induced psoriatic like dermatitis in mice |
| topic | aloe sinkatana dermatitis extracts imiquimod (imq) psoriasis area and severity index (pasi) mice |
| url | http://pbr.mazums.ac.ir/article-1-658-en.pdf |
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