Reduction of the Ca2+ permeability of ligand-gated ion channels as a strategy against excitotoxicity
Excitotoxic damage is due to an excessive Ca2+ entry in cells following overactivation of Ca2+-permeable ion channels. In neurons, Ca2+-dependent excitotoxicity is linked to the prominent activation of N-Methyl-d-Aspartate receptors (NMDARs), exhibiting a high permeability to Ca2+. Different neurode...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2025.1617006/full |
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