Genome-Wide Association Study for the Capacity to Skip the Dry Period in Dairy Goats
Lactation is a challenging life stage for dairy animals, as they need to cope with milk production and, in most cases, simultaneous pregnancy. The dry period between two consecutive lactations can be a producer choice, based on, for instance, animal performance or a physiological requirement when an...
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MDPI AG
2025-03-01
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| Series: | Agriculture |
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| author | Bruno A. Galindo Erin Massender Isis C. Hermisdorff Flavio S. Schenkel |
| author_facet | Bruno A. Galindo Erin Massender Isis C. Hermisdorff Flavio S. Schenkel |
| author_sort | Bruno A. Galindo |
| collection | DOAJ |
| description | Lactation is a challenging life stage for dairy animals, as they need to cope with milk production and, in most cases, simultaneous pregnancy. The dry period between two consecutive lactations can be a producer choice, based on, for instance, animal performance or a physiological requirement when animals dry off spontaneously. The goals of this research were to estimate genetic parameters and perform a genome-wide association study in Saanen goats for the capacity to skip the dry period between lactations to identify genes and QTLs underlying this trait. A total of 249 Saanen dairy goats had the length of their dry period determined over lactations, with some (n = 54) showing the capacity to skip the dry period, i.e., having a dry period of a single day. The estimated heritability for the capacity to skip the dry period was moderate (0.25, SE = 0.13). Three SNPs significantly associated with the capacity to skip dry period were identified, which are located close to the <i>OSMR</i> gene, reported to be associated with mammary involution, and a known QTL for cannon bone circumference. The three SNPs were also confined to a very conserved region on chromosome 20, which harbors several genes associated with milk-related traits. The <i>OSMR</i> gene seems to be a good candidate gene for the capacity to skip the dry period, and the genomic region where it is located appears to also be important for milk production traits. |
| format | Article |
| id | doaj-art-6fba6add11eb406782af2db47cf0cb9b |
| institution | DOAJ |
| issn | 2077-0472 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
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| series | Agriculture |
| spelling | doaj-art-6fba6add11eb406782af2db47cf0cb9b2025-08-20T02:41:48ZengMDPI AGAgriculture2077-04722025-03-0115662210.3390/agriculture15060622Genome-Wide Association Study for the Capacity to Skip the Dry Period in Dairy GoatsBruno A. Galindo0Erin Massender1Isis C. Hermisdorff2Flavio S. Schenkel3Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, CanadaAgSights, Elora, ON N0B 1S0, CanadaDepartment of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, CanadaDepartment of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, CanadaLactation is a challenging life stage for dairy animals, as they need to cope with milk production and, in most cases, simultaneous pregnancy. The dry period between two consecutive lactations can be a producer choice, based on, for instance, animal performance or a physiological requirement when animals dry off spontaneously. The goals of this research were to estimate genetic parameters and perform a genome-wide association study in Saanen goats for the capacity to skip the dry period between lactations to identify genes and QTLs underlying this trait. A total of 249 Saanen dairy goats had the length of their dry period determined over lactations, with some (n = 54) showing the capacity to skip the dry period, i.e., having a dry period of a single day. The estimated heritability for the capacity to skip the dry period was moderate (0.25, SE = 0.13). Three SNPs significantly associated with the capacity to skip dry period were identified, which are located close to the <i>OSMR</i> gene, reported to be associated with mammary involution, and a known QTL for cannon bone circumference. The three SNPs were also confined to a very conserved region on chromosome 20, which harbors several genes associated with milk-related traits. The <i>OSMR</i> gene seems to be a good candidate gene for the capacity to skip the dry period, and the genomic region where it is located appears to also be important for milk production traits.https://www.mdpi.com/2077-0472/15/6/622dry periodOSMRlactationassociation studies |
| spellingShingle | Bruno A. Galindo Erin Massender Isis C. Hermisdorff Flavio S. Schenkel Genome-Wide Association Study for the Capacity to Skip the Dry Period in Dairy Goats Agriculture dry period OSMR lactation association studies |
| title | Genome-Wide Association Study for the Capacity to Skip the Dry Period in Dairy Goats |
| title_full | Genome-Wide Association Study for the Capacity to Skip the Dry Period in Dairy Goats |
| title_fullStr | Genome-Wide Association Study for the Capacity to Skip the Dry Period in Dairy Goats |
| title_full_unstemmed | Genome-Wide Association Study for the Capacity to Skip the Dry Period in Dairy Goats |
| title_short | Genome-Wide Association Study for the Capacity to Skip the Dry Period in Dairy Goats |
| title_sort | genome wide association study for the capacity to skip the dry period in dairy goats |
| topic | dry period OSMR lactation association studies |
| url | https://www.mdpi.com/2077-0472/15/6/622 |
| work_keys_str_mv | AT brunoagalindo genomewideassociationstudyforthecapacitytoskipthedryperiodindairygoats AT erinmassender genomewideassociationstudyforthecapacitytoskipthedryperiodindairygoats AT isischermisdorff genomewideassociationstudyforthecapacitytoskipthedryperiodindairygoats AT flaviosschenkel genomewideassociationstudyforthecapacitytoskipthedryperiodindairygoats |