Structural difference analysis of gut microbiota in different bone mass populations and relevant probiotic (lactobacilli) supplementation strategies
Abstract Disruption of the bone metabolic balance with advancing age leads to an escalating prevalence of bone‐related diseases, significantly compromising individuals’ quality of life. The gut microbiota actively participates in the regulation of bone metabolism, and perturbations in the gut microb...
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| Format: | Article |
| Language: | English |
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Wiley
2024-09-01
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| Series: | Food Frontiers |
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| Online Access: | https://doi.org/10.1002/fft2.449 |
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| author | Jiani Pan Pingping Yin Leilei Yu Heng Zhang Chengcheng Zhang Jianxin Zhao Fengwei Tian Qixiao Zhai |
| author_facet | Jiani Pan Pingping Yin Leilei Yu Heng Zhang Chengcheng Zhang Jianxin Zhao Fengwei Tian Qixiao Zhai |
| author_sort | Jiani Pan |
| collection | DOAJ |
| description | Abstract Disruption of the bone metabolic balance with advancing age leads to an escalating prevalence of bone‐related diseases, significantly compromising individuals’ quality of life. The gut microbiota actively participates in the regulation of bone metabolism, and perturbations in the gut microbiota can exacerbate bone diseases by compromising gut barrier integrity. Determining the microbial taxa involved in bone loss could offer valuable insights into the development of alternative therapies and nutritional interventions for disease management. Therefore, based on metagenomic and 16S ribosomal RNA data, this study analyzed the gut microbiota structure of 488 individuals with different bone masses (NC, normal; ON, osteopenia; OP, osteoporosis) to identify significant associations between the gut microbiota and bone loss. The results showed that at the genus and species levels, the microbiota diversity of the ON population increased, whereas that of the OP population decreased. Bacteroides were significantly enriched in the OP population, whereas the beneficial bacteria Bifidobacterium, Akkermansia, and lactobacilli decreased. Subsequent analyses revealed no significant variation in different bone populations in terms of Bifidobacterium levels, whereas lactobacilli exhibited diverse responses across distinct bone populations. The administration of lactobacilli effectively enhanced lumbar spine bone mineral density and modulated the gut microbiota structure in a population with unhealthy bone mass. This study contributes to the validation of the association between the gut microbiota and bone mass, enhances our understanding of the potential impact of probiotics (lactobacilli) on bone mass, and establishes a robust scientific basis for the application of probiotics in the regulation of bone mass. |
| format | Article |
| id | doaj-art-6fb5853ba5ee44ea89613d5b4ad35715 |
| institution | Kabale University |
| issn | 2643-8429 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Frontiers |
| spelling | doaj-art-6fb5853ba5ee44ea89613d5b4ad357152024-11-17T09:43:58ZengWileyFood Frontiers2643-84292024-09-01552122213610.1002/fft2.449Structural difference analysis of gut microbiota in different bone mass populations and relevant probiotic (lactobacilli) supplementation strategiesJiani Pan0Pingping Yin1Leilei Yu2Heng Zhang3Chengcheng Zhang4Jianxin Zhao5Fengwei Tian6Qixiao Zhai7State Key Laboratory of Food Science and Resources Jiangnan University Wuxi Jiangsu ChinaState Key Laboratory of Food Science and Resources Jiangnan University Wuxi Jiangsu ChinaState Key Laboratory of Food Science and Resources Jiangnan University Wuxi Jiangsu ChinaWuxi School of Medicine Jiangnan University Wuxi Jiangsu ChinaState Key Laboratory of Food Science and Resources Jiangnan University Wuxi Jiangsu ChinaState Key Laboratory of Food Science and Resources Jiangnan University Wuxi Jiangsu ChinaState Key Laboratory of Food Science and Resources Jiangnan University Wuxi Jiangsu ChinaState Key Laboratory of Food Science and Resources Jiangnan University Wuxi Jiangsu ChinaAbstract Disruption of the bone metabolic balance with advancing age leads to an escalating prevalence of bone‐related diseases, significantly compromising individuals’ quality of life. The gut microbiota actively participates in the regulation of bone metabolism, and perturbations in the gut microbiota can exacerbate bone diseases by compromising gut barrier integrity. Determining the microbial taxa involved in bone loss could offer valuable insights into the development of alternative therapies and nutritional interventions for disease management. Therefore, based on metagenomic and 16S ribosomal RNA data, this study analyzed the gut microbiota structure of 488 individuals with different bone masses (NC, normal; ON, osteopenia; OP, osteoporosis) to identify significant associations between the gut microbiota and bone loss. The results showed that at the genus and species levels, the microbiota diversity of the ON population increased, whereas that of the OP population decreased. Bacteroides were significantly enriched in the OP population, whereas the beneficial bacteria Bifidobacterium, Akkermansia, and lactobacilli decreased. Subsequent analyses revealed no significant variation in different bone populations in terms of Bifidobacterium levels, whereas lactobacilli exhibited diverse responses across distinct bone populations. The administration of lactobacilli effectively enhanced lumbar spine bone mineral density and modulated the gut microbiota structure in a population with unhealthy bone mass. This study contributes to the validation of the association between the gut microbiota and bone mass, enhances our understanding of the potential impact of probiotics (lactobacilli) on bone mass, and establishes a robust scientific basis for the application of probiotics in the regulation of bone mass.https://doi.org/10.1002/fft2.449bone lossgut microbiotalactobacilliosteoporosisprobiotics |
| spellingShingle | Jiani Pan Pingping Yin Leilei Yu Heng Zhang Chengcheng Zhang Jianxin Zhao Fengwei Tian Qixiao Zhai Structural difference analysis of gut microbiota in different bone mass populations and relevant probiotic (lactobacilli) supplementation strategies Food Frontiers bone loss gut microbiota lactobacilli osteoporosis probiotics |
| title | Structural difference analysis of gut microbiota in different bone mass populations and relevant probiotic (lactobacilli) supplementation strategies |
| title_full | Structural difference analysis of gut microbiota in different bone mass populations and relevant probiotic (lactobacilli) supplementation strategies |
| title_fullStr | Structural difference analysis of gut microbiota in different bone mass populations and relevant probiotic (lactobacilli) supplementation strategies |
| title_full_unstemmed | Structural difference analysis of gut microbiota in different bone mass populations and relevant probiotic (lactobacilli) supplementation strategies |
| title_short | Structural difference analysis of gut microbiota in different bone mass populations and relevant probiotic (lactobacilli) supplementation strategies |
| title_sort | structural difference analysis of gut microbiota in different bone mass populations and relevant probiotic lactobacilli supplementation strategies |
| topic | bone loss gut microbiota lactobacilli osteoporosis probiotics |
| url | https://doi.org/10.1002/fft2.449 |
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