Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis
Since the emergence of pathogenic non-albicans Candida species, a number of new isolates have been added to the list. One such unusual species is Candida auris (C. auris), recently isolated and studied in few reports. In this study, a case of vulvovaginitis caused by Candida auris incidentally ident...
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| Format: | Article |
| Language: | English |
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The Journal of Infection in Developing Countries
2015-04-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/4582 |
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| author | Dharmendra Kumar Tuhina Banerjee Chandra Bhan Pratap Ragini Tilak |
| author_facet | Dharmendra Kumar Tuhina Banerjee Chandra Bhan Pratap Ragini Tilak |
| author_sort | Dharmendra Kumar |
| collection | DOAJ |
| description | Since the emergence of pathogenic non-albicans Candida species, a number of new isolates have been added to the list. One such unusual species is Candida auris (C. auris), recently isolated and studied in few reports. In this study, a case of vulvovaginitis caused by Candida auris incidentally identified by molecular methods using internal transcribed spacer polymerase chain reaction (ITS PCR) is described. Antifungal susceptibility testing revealed the isolate to be resistant to itraconazole (MIC ≥ 2 µg/ml) and expressed important virulence factors including phospholipase, proteinase and hemolysin activity. The patient was successfully treated with oral fluconazole and did not have any invasive fungemia.
Very few cases of this emerging pathogen have been reported. However, its isolation from clinical specimens reveals the significance of non-albicans candida species over C. albicans and the diversity of Candida spp causing infections.
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| format | Article |
| id | doaj-art-6fb1ee73cb3c41edb3c36c1bc6994b03 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2015-04-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-6fb1ee73cb3c41edb3c36c1bc6994b032025-08-20T03:48:46ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802015-04-0190410.3855/jidc.4582Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitisDharmendra Kumar0Tuhina Banerjee1Chandra Bhan Pratap2Ragini Tilak3Institute of Medical Sciences, Banaras Hindu University, Varanasi, IndiaInstitute of Medical Sciences, Banaras Hindu University, Varanasi, IndiaInstitute of Medical Sciences, Banaras Hindu University, Varanasi, IndiaInstitute of Medical Sciences, Banaras Hindu University, Varanasi, IndiaSince the emergence of pathogenic non-albicans Candida species, a number of new isolates have been added to the list. One such unusual species is Candida auris (C. auris), recently isolated and studied in few reports. In this study, a case of vulvovaginitis caused by Candida auris incidentally identified by molecular methods using internal transcribed spacer polymerase chain reaction (ITS PCR) is described. Antifungal susceptibility testing revealed the isolate to be resistant to itraconazole (MIC ≥ 2 µg/ml) and expressed important virulence factors including phospholipase, proteinase and hemolysin activity. The patient was successfully treated with oral fluconazole and did not have any invasive fungemia. Very few cases of this emerging pathogen have been reported. However, its isolation from clinical specimens reveals the significance of non-albicans candida species over C. albicans and the diversity of Candida spp causing infections. https://jidc.org/index.php/journal/article/view/4582C. aurisnon-albicansresistancephospholipase |
| spellingShingle | Dharmendra Kumar Tuhina Banerjee Chandra Bhan Pratap Ragini Tilak Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis Journal of Infection in Developing Countries C. auris non-albicans resistance phospholipase |
| title | Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis |
| title_full | Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis |
| title_fullStr | Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis |
| title_full_unstemmed | Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis |
| title_short | Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis |
| title_sort | itraconazole resistant candida auris with phospholipase proteinase and hemolysin activity from a case of vulvovaginitis |
| topic | C. auris non-albicans resistance phospholipase |
| url | https://jidc.org/index.php/journal/article/view/4582 |
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