Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications
Yuyue Qiu, Xiaoni Shao College of Pharmacy and Food, Southwest Minzu University, Chengdu, Sichuan, 610225, People’s Republic of ChinaCorrespondence: Xiaoni Shao, College of Pharmacy and Food, Southwest Minzu University, #168 Dajian Street, Shuangliu District, Chengdu, 610225, People’s Re...
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Dove Medical Press
2025-07-01
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| author | Qiu Y Shao X |
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| collection | DOAJ |
| description | Yuyue Qiu, Xiaoni Shao College of Pharmacy and Food, Southwest Minzu University, Chengdu, Sichuan, 610225, People’s Republic of ChinaCorrespondence: Xiaoni Shao, College of Pharmacy and Food, Southwest Minzu University, #168 Dajian Street, Shuangliu District, Chengdu, 610225, People’s Republic of China, Tel +86-28-85738423, Email xnshao@swun.edu.cnAbstract: Histone lactylation, as a common post-translational modification (PTM), is crucial in diseases. Aberrant histone lactylation has been linked to disease pathogenesis, thus positioning it as a therapeutic target. This review summarizes the bidirectional relationship between histone lactylation and diseases, emphasizing how Traditional Chinese medicine (TCM) regulates lactate levels to restore histone lactylation homeostasis. Mechanistically, TCM modulates histone lactylation through dual regulation of lactyltransferases and lactate metabolism, thereby influencing disease progression in inflammatory, metabolic, and neoplastic disorders. Notably, TCM is characterized by unique advantages of cost-effectiveness, high efficacy, and minimal adverse effects. For diseases with established drug resistance, TCM offers a promising therapeutic alternative in managing drug-resistant illness by regulating histone lactylation. This review is conducive to understanding the relationship between histone lactylation and disease. TCM effectively treats diseases through the regulation of histone lactylation, thereby highlighting its potential for disease treatment application. Keywords: histone lactylation, disease, Traditional Chinese medicine, mechanism, therapeutic target |
| format | Article |
| id | doaj-art-6fae53cbbab34e1e96b3fffec85fc008 |
| institution | DOAJ |
| issn | 1177-8881 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj-art-6fae53cbbab34e1e96b3fffec85fc0082025-08-20T03:09:25ZengDove Medical PressDrug Design, Development and Therapy1177-88812025-07-01Volume 19Issue 164356459105273Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic ImplicationsQiu Y0Shao X1College of Pharmacy and FoodCollege of Pharmacy and FoodYuyue Qiu, Xiaoni Shao College of Pharmacy and Food, Southwest Minzu University, Chengdu, Sichuan, 610225, People’s Republic of ChinaCorrespondence: Xiaoni Shao, College of Pharmacy and Food, Southwest Minzu University, #168 Dajian Street, Shuangliu District, Chengdu, 610225, People’s Republic of China, Tel +86-28-85738423, Email xnshao@swun.edu.cnAbstract: Histone lactylation, as a common post-translational modification (PTM), is crucial in diseases. Aberrant histone lactylation has been linked to disease pathogenesis, thus positioning it as a therapeutic target. This review summarizes the bidirectional relationship between histone lactylation and diseases, emphasizing how Traditional Chinese medicine (TCM) regulates lactate levels to restore histone lactylation homeostasis. Mechanistically, TCM modulates histone lactylation through dual regulation of lactyltransferases and lactate metabolism, thereby influencing disease progression in inflammatory, metabolic, and neoplastic disorders. Notably, TCM is characterized by unique advantages of cost-effectiveness, high efficacy, and minimal adverse effects. For diseases with established drug resistance, TCM offers a promising therapeutic alternative in managing drug-resistant illness by regulating histone lactylation. This review is conducive to understanding the relationship between histone lactylation and disease. TCM effectively treats diseases through the regulation of histone lactylation, thereby highlighting its potential for disease treatment application. Keywords: histone lactylation, disease, Traditional Chinese medicine, mechanism, therapeutic targethttps://www.dovepress.com/histone-lactylation-in-diseases-regulation-by-traditional-chinese-medi-peer-reviewed-fulltext-article-DDDTHistone lactylationDiseaseTraditional Chinese medicineMechanismTherapeutic target |
| spellingShingle | Qiu Y Shao X Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications Drug Design, Development and Therapy Histone lactylation Disease Traditional Chinese medicine Mechanism Therapeutic target |
| title | Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications |
| title_full | Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications |
| title_fullStr | Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications |
| title_full_unstemmed | Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications |
| title_short | Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications |
| title_sort | histone lactylation in diseases regulation by traditional chinese medicine and therapeutic implications |
| topic | Histone lactylation Disease Traditional Chinese medicine Mechanism Therapeutic target |
| url | https://www.dovepress.com/histone-lactylation-in-diseases-regulation-by-traditional-chinese-medi-peer-reviewed-fulltext-article-DDDT |
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