Effect of Mesenchymal Stem Cell-Derived Exosomes on Retinal Injury: A Review of Current Findings
In recent years, various studies have followed in the literature on the therapeutic effects of mesenchymal stem cells (MSC) on damage in retinal cells. The evidence that MSCs exert their regenerative and damage reduction effect in a paracrine way, through the release of soluble factors and exosomes,...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/8883616 |
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| author | Raffaele Nuzzi Paolo Caselgrandi Alessandro Vercelli |
| author_facet | Raffaele Nuzzi Paolo Caselgrandi Alessandro Vercelli |
| author_sort | Raffaele Nuzzi |
| collection | DOAJ |
| description | In recent years, various studies have followed in the literature on the therapeutic effects of mesenchymal stem cells (MSC) on damage in retinal cells. The evidence that MSCs exert their regenerative and damage reduction effect in a paracrine way, through the release of soluble factors and exosomes, is now consolidated. Exosomes are microvesicles formed by a double layer of phospholipid membrane and carry proteins and RNA, through which they play a therapeutic role on target cells. Scientific research has recently focused on the use of exosomes derived from MSC in various models of retinal damage in vitro and in vivo as they, compared to MSCs, have similar functions and at the same time have different advantages such as greater stability and handling, a lower chance of immunological rejection and no risk of malignant transformation. The purpose of this review is to summarize current knowledge on the therapeutic use of exosomes derived from MSCs in retinal damage and to stimulate new clinical perspectives regarding their use. |
| format | Article |
| id | doaj-art-6fad215b7d23456d9901c0442dfc73b5 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-6fad215b7d23456d9901c0442dfc73b52025-02-03T00:58:52ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/88836168883616Effect of Mesenchymal Stem Cell-Derived Exosomes on Retinal Injury: A Review of Current FindingsRaffaele Nuzzi0Paolo Caselgrandi1Alessandro Vercelli2Eye Clinic, Department of Surgical Sciences, University of Turin, Turin, ItalyEye Clinic, Department of Surgical Sciences, University of Turin, Turin, ItalyDepartment of Neuroscience Rita Levi Montalcini, University of Turin, Turin, ItalyIn recent years, various studies have followed in the literature on the therapeutic effects of mesenchymal stem cells (MSC) on damage in retinal cells. The evidence that MSCs exert their regenerative and damage reduction effect in a paracrine way, through the release of soluble factors and exosomes, is now consolidated. Exosomes are microvesicles formed by a double layer of phospholipid membrane and carry proteins and RNA, through which they play a therapeutic role on target cells. Scientific research has recently focused on the use of exosomes derived from MSC in various models of retinal damage in vitro and in vivo as they, compared to MSCs, have similar functions and at the same time have different advantages such as greater stability and handling, a lower chance of immunological rejection and no risk of malignant transformation. The purpose of this review is to summarize current knowledge on the therapeutic use of exosomes derived from MSCs in retinal damage and to stimulate new clinical perspectives regarding their use.http://dx.doi.org/10.1155/2020/8883616 |
| spellingShingle | Raffaele Nuzzi Paolo Caselgrandi Alessandro Vercelli Effect of Mesenchymal Stem Cell-Derived Exosomes on Retinal Injury: A Review of Current Findings Stem Cells International |
| title | Effect of Mesenchymal Stem Cell-Derived Exosomes on Retinal Injury: A Review of Current Findings |
| title_full | Effect of Mesenchymal Stem Cell-Derived Exosomes on Retinal Injury: A Review of Current Findings |
| title_fullStr | Effect of Mesenchymal Stem Cell-Derived Exosomes on Retinal Injury: A Review of Current Findings |
| title_full_unstemmed | Effect of Mesenchymal Stem Cell-Derived Exosomes on Retinal Injury: A Review of Current Findings |
| title_short | Effect of Mesenchymal Stem Cell-Derived Exosomes on Retinal Injury: A Review of Current Findings |
| title_sort | effect of mesenchymal stem cell derived exosomes on retinal injury a review of current findings |
| url | http://dx.doi.org/10.1155/2020/8883616 |
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