Perioperative treatment with cilostazol reverses steatosis and improves liver regeneration after major hepatectomy in a steatotic rat model

Perioperative treatment with cilostazol reverses steatosis and improves liver regeneration after major hepatectomy in a steatotic rat model

Abstract Cilostazol has previously been shown to reduce liver steatosis and enhance hepatic perfusion. We investigated the effects of cilostazol after major hepatectomy in a steatotic rat model. Six weeks prior to surgery, Sprague–Dawley rats were fed with a high-fructose diet. The treatment group r...

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Bibliographic Details
Main Authors: Sebastian Holländer, Maximilian von Heesen, Gereon Gäbelein, Julie Mercier, Matthias W. Laschke, Michael D. Menger, Matthias Glanemann, Antonios E. Spiliotis
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Obesity
Non-alcoholic fatty liver disease
Hepatectomy
Cilostazol
Liver regeneration
Online Access:https://doi.org/10.1038/s41598-025-87135-z
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