Use of CytoSorb in Traumatic Amputation of the Forearm and Severe Septic Shock
Severe trauma associated with later disability and mortality still constitutes a major health and socioeconomic problem throughout the world. While primary morbidity and mortality are mostly related to initial injuries and early complications, secondary lethality is strongly linked to the developmen...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2017/8747616 |
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| author | Heinz Steltzer Alexander Grieb Karim Mostafa Reinhard Berger |
| author_facet | Heinz Steltzer Alexander Grieb Karim Mostafa Reinhard Berger |
| author_sort | Heinz Steltzer |
| collection | DOAJ |
| description | Severe trauma associated with later disability and mortality still constitutes a major health and socioeconomic problem throughout the world. While primary morbidity and mortality are mostly related to initial injuries and early complications, secondary lethality is strongly linked to the development of systemic inflammatory response syndrome, sepsis, and ultimately multiple organ dysfunction syndrome. We herein report on a 49-year-old male patient who was admitted to the hospital after a traumatic amputation of his right forearm that was cut off while working on a landfill. After initial treatment for shock, he received immediate replantation and was transferred to the ICU. Due to the anticipated risk of a complex infection, continuous renal replacement therapy in combination with CytoSorb was initiated. During the course of the combined treatment, a rapid improvement in hemodynamics was noticed, as well as a significant reduction of IL-6 and lactate levels. Despite a recurring septic episode and the necessity for amputation, the patient clinically stabilized and underwent complete recovery. The early treatment with a combination of CVVHDF and CytoSorb was accompanied by an attenuation of the systemic inflammatory reaction, which subsided without major or permanent organ damage, despite the impressive pathogen spectrum and the pronounced local damage. |
| format | Article |
| id | doaj-art-6fac02098a5441a5a4a30e956dce6fa5 |
| institution | OA Journals |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-6fac02098a5441a5a4a30e956dce6fa52025-08-20T02:06:13ZengWileyCase Reports in Critical Care2090-64202090-64392017-01-01201710.1155/2017/87476168747616Use of CytoSorb in Traumatic Amputation of the Forearm and Severe Septic ShockHeinz Steltzer0Alexander Grieb1Karim Mostafa2Reinhard Berger3AUVA-Unfallkrankenhaus Meidling, Department of Anesthesiology and Intensive Care Medicine, Vienna, AustriaAUVA-Unfallkrankenhaus Meidling, Department of Anesthesiology and Intensive Care Medicine, Vienna, AustriaAUVA-Unfallkrankenhaus Meidling, Department of Anesthesiology and Intensive Care Medicine, Vienna, AustriaAUVA-Unfallkrankenhaus Meidling, Department of Anesthesiology and Intensive Care Medicine, Vienna, AustriaSevere trauma associated with later disability and mortality still constitutes a major health and socioeconomic problem throughout the world. While primary morbidity and mortality are mostly related to initial injuries and early complications, secondary lethality is strongly linked to the development of systemic inflammatory response syndrome, sepsis, and ultimately multiple organ dysfunction syndrome. We herein report on a 49-year-old male patient who was admitted to the hospital after a traumatic amputation of his right forearm that was cut off while working on a landfill. After initial treatment for shock, he received immediate replantation and was transferred to the ICU. Due to the anticipated risk of a complex infection, continuous renal replacement therapy in combination with CytoSorb was initiated. During the course of the combined treatment, a rapid improvement in hemodynamics was noticed, as well as a significant reduction of IL-6 and lactate levels. Despite a recurring septic episode and the necessity for amputation, the patient clinically stabilized and underwent complete recovery. The early treatment with a combination of CVVHDF and CytoSorb was accompanied by an attenuation of the systemic inflammatory reaction, which subsided without major or permanent organ damage, despite the impressive pathogen spectrum and the pronounced local damage.http://dx.doi.org/10.1155/2017/8747616 |
| spellingShingle | Heinz Steltzer Alexander Grieb Karim Mostafa Reinhard Berger Use of CytoSorb in Traumatic Amputation of the Forearm and Severe Septic Shock Case Reports in Critical Care |
| title | Use of CytoSorb in Traumatic Amputation of the Forearm and Severe Septic Shock |
| title_full | Use of CytoSorb in Traumatic Amputation of the Forearm and Severe Septic Shock |
| title_fullStr | Use of CytoSorb in Traumatic Amputation of the Forearm and Severe Septic Shock |
| title_full_unstemmed | Use of CytoSorb in Traumatic Amputation of the Forearm and Severe Septic Shock |
| title_short | Use of CytoSorb in Traumatic Amputation of the Forearm and Severe Septic Shock |
| title_sort | use of cytosorb in traumatic amputation of the forearm and severe septic shock |
| url | http://dx.doi.org/10.1155/2017/8747616 |
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