The predictors of lymphopenia and its effects on survival in locally advanced esophageal squamous cell carcinoma
To investigate the impact of the effective radiation dose to immune cells (EDIC) and gross tumor volume (GTV) on lymphopenia and survival in patients with locally advanced esophageal squamous cell carcinoma (LAESCC). Between January 2013 and December 2020, 272 LAESCC patients were treated with defin...
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Taylor & Francis Group
2024-12-01
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| Series: | Cancer Biology & Therapy |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15384047.2024.2371632 |
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| author | Danjing Luo Qiulu Zhong Haiying Yue Jue Wang Qianfu Liang Wenqi Liu Xiaodong Zhu |
| author_facet | Danjing Luo Qiulu Zhong Haiying Yue Jue Wang Qianfu Liang Wenqi Liu Xiaodong Zhu |
| author_sort | Danjing Luo |
| collection | DOAJ |
| description | To investigate the impact of the effective radiation dose to immune cells (EDIC) and gross tumor volume (GTV) on lymphopenia and survival in patients with locally advanced esophageal squamous cell carcinoma (LAESCC). Between January 2013 and December 2020, 272 LAESCC patients were treated with definitive radiotherapy in two institutions. Based on radiation doses to the lungs, heart, and body region scanned, EDIC was calculated as an equal uniform dose to the total blood considering blood flow and fraction effect. The radiotherapy plan was used to calculate the GTVs. Lymphopenia was graded based on the lowest lymphocyte count during RT. The overall survival (OS), progress-free survival (PFS), and local recurrence-free survival (LRFS) were analyzed statistically. The lowest lymphocyte count was significantly correlated with EDIC (r= −0.389, p < .001) and GTV (r= −0.211, p < .001). Lymphopenia, EDIC, and GTV are risk factors for patients with ESCC. In a Kaplan-Meier analysis with EDIC and GTV as stratification factors, lymphopenia was not associated with OS in the EDIC>12.9 Gy group (p = .294)and EDIC ≤ 12.9 Gy group, and it was also not associated with OS in GTV>68.8 cm3 group (p = .242) and GTV ≤ 68.8 cm3 group(p = .165). GTV and EDIC had an impact on the relationship between lymphopenia and OS in patients with LAESCC undergoing definitive RT. Poorer OS, PFS, and LRFS are correlated with lymphopenia, higher EDIC, and larger GTV. |
| format | Article |
| id | doaj-art-6fa3599f74f94d41b5ac7eaaedf2e8c1 |
| institution | OA Journals |
| issn | 1538-4047 1555-8576 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj-art-6fa3599f74f94d41b5ac7eaaedf2e8c12025-08-20T02:38:13ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762024-12-0125110.1080/15384047.2024.2371632The predictors of lymphopenia and its effects on survival in locally advanced esophageal squamous cell carcinomaDanjing Luo0Qiulu Zhong1Haiying Yue2Jue Wang3Qianfu Liang4Wenqi Liu5Xiaodong Zhu6Department of Radiation Oncology, Second Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Radiation Oncology, Second Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Radiation Oncology, Second Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Radiation Oncology, Second Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Radiation Oncology, Second Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Radiation Oncology, Second Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, ChinaTo investigate the impact of the effective radiation dose to immune cells (EDIC) and gross tumor volume (GTV) on lymphopenia and survival in patients with locally advanced esophageal squamous cell carcinoma (LAESCC). Between January 2013 and December 2020, 272 LAESCC patients were treated with definitive radiotherapy in two institutions. Based on radiation doses to the lungs, heart, and body region scanned, EDIC was calculated as an equal uniform dose to the total blood considering blood flow and fraction effect. The radiotherapy plan was used to calculate the GTVs. Lymphopenia was graded based on the lowest lymphocyte count during RT. The overall survival (OS), progress-free survival (PFS), and local recurrence-free survival (LRFS) were analyzed statistically. The lowest lymphocyte count was significantly correlated with EDIC (r= −0.389, p < .001) and GTV (r= −0.211, p < .001). Lymphopenia, EDIC, and GTV are risk factors for patients with ESCC. In a Kaplan-Meier analysis with EDIC and GTV as stratification factors, lymphopenia was not associated with OS in the EDIC>12.9 Gy group (p = .294)and EDIC ≤ 12.9 Gy group, and it was also not associated with OS in GTV>68.8 cm3 group (p = .242) and GTV ≤ 68.8 cm3 group(p = .165). GTV and EDIC had an impact on the relationship between lymphopenia and OS in patients with LAESCC undergoing definitive RT. Poorer OS, PFS, and LRFS are correlated with lymphopenia, higher EDIC, and larger GTV.https://www.tandfonline.com/doi/10.1080/15384047.2024.2371632Lymphopeniathe effective radiation dose to immune cellsesophageal squamous cell carcinomadefinitive radiation therapygross tumor volumesurvival |
| spellingShingle | Danjing Luo Qiulu Zhong Haiying Yue Jue Wang Qianfu Liang Wenqi Liu Xiaodong Zhu The predictors of lymphopenia and its effects on survival in locally advanced esophageal squamous cell carcinoma Cancer Biology & Therapy Lymphopenia the effective radiation dose to immune cells esophageal squamous cell carcinoma definitive radiation therapy gross tumor volume survival |
| title | The predictors of lymphopenia and its effects on survival in locally advanced esophageal squamous cell carcinoma |
| title_full | The predictors of lymphopenia and its effects on survival in locally advanced esophageal squamous cell carcinoma |
| title_fullStr | The predictors of lymphopenia and its effects on survival in locally advanced esophageal squamous cell carcinoma |
| title_full_unstemmed | The predictors of lymphopenia and its effects on survival in locally advanced esophageal squamous cell carcinoma |
| title_short | The predictors of lymphopenia and its effects on survival in locally advanced esophageal squamous cell carcinoma |
| title_sort | predictors of lymphopenia and its effects on survival in locally advanced esophageal squamous cell carcinoma |
| topic | Lymphopenia the effective radiation dose to immune cells esophageal squamous cell carcinoma definitive radiation therapy gross tumor volume survival |
| url | https://www.tandfonline.com/doi/10.1080/15384047.2024.2371632 |
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