HIF-1α alleviates ferroptosis in ulcerative colitis by regulation of GPX4

HIF-1α alleviates ferroptosis in ulcerative colitis by regulation of GPX4

Abstract Ferroptosis is an iron-dependent form of regulated cell death induced by the lethal accumulation of lipid peroxidation, while the precise mechanism of ferroptosis in the pathogenesis of ulcerative colitis (UC) remains to be elucidated. This study aimed to explore the potential effect of hyp...

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Main Authors: Weitao Hu, Yanliang Cai, Daxing Cai, Zongchi Chen, Siying Huang, Su Zhang, Huie Zhuang, Taiyong Fang, Xiaoqing Chen
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07883-8
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