Acoustic therapy for allergic rhinitis and chronic rhinosinusitis: modulating microbiome, immunity and well-being
Allergic rhinitis (AR) and chronic rhinosinusitis (CRS) are common respiratory conditions that significantly impact patient health and contribute to substantial healthcare burdens. While conventional treatments offer symptom relief, many patients continue to experience persistent symptoms, side effe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Allergy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/falgy.2025.1649031/full |
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| author | Jude Oluwapelumi Alao Kelvin E. M. Lau David White Kevin Lee Chris Puli'uvea Jim Bartley |
| author_facet | Jude Oluwapelumi Alao Kelvin E. M. Lau David White Kevin Lee Chris Puli'uvea Jim Bartley |
| author_sort | Jude Oluwapelumi Alao |
| collection | DOAJ |
| description | Allergic rhinitis (AR) and chronic rhinosinusitis (CRS) are common respiratory conditions that significantly impact patient health and contribute to substantial healthcare burdens. While conventional treatments offer symptom relief, many patients continue to experience persistent symptoms, side effects, or resistance to standard therapies. This highlights the growing need for novel, non-invasive, and sustainable therapeutic strategies to manage chronic airway inflammation. This review examines acoustic therapy, an emerging non-pharmacological treatment that uses sound wave-induced vibrations as a potential adjunctive therapy for AR and CRS. Acoustic therapy shows potential benefits, including enhanced nitric oxide production, improved mucociliary clearance, and modulation of immune responses by activating mechanosensitive pathways and disrupting pathogenic biofilms. Preliminary clinical findings across some trials have reported improvements in peak nasal inspiratory flow ranging from approximately 17% to 31%, significant reductions in nasal congestion and symptom scores, such as Total Nasal Symptom Score, Sino-Nasal Outcome Test-22 (SNOT-22), and enhancements in sleep quality and patient-reported outcomes. Given this limited but expanding body of evidence, we integrate interdisciplinary insights from respiratory medicine, immunology, and microbiome science to provide a translational framework for future research. We highlight the need for rigorously designed clinical trials to assess acoustic therapy's therapeutic efficacy, safety, and long-term impact. As this field evolves, acoustic therapy holds significant potential to address unmet needs in chronic respiratory diseases and contributes to improved patient care. |
| format | Article |
| id | doaj-art-6f8652fdbdd64a3a83006169209fc39e |
| institution | Kabale University |
| issn | 2673-6101 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Allergy |
| spelling | doaj-art-6f8652fdbdd64a3a83006169209fc39e2025-08-25T05:25:26ZengFrontiers Media S.A.Frontiers in Allergy2673-61012025-08-01610.3389/falgy.2025.16490311649031Acoustic therapy for allergic rhinitis and chronic rhinosinusitis: modulating microbiome, immunity and well-beingJude Oluwapelumi Alao0Kelvin E. M. Lau1David White2Kevin Lee3Chris Puli'uvea4Jim Bartley5School of Public Health and Interdisciplinary Studies, Auckland University of Technology, Auckland, New ZealandSchool of Public Health and Interdisciplinary Studies, Auckland University of Technology, Auckland, New ZealandCentre of Chiropractic Research, New Zealand College of Chiropractic, Auckland, New ZealandSchool of Science, Auckland University of Technology, Auckland, New ZealandSchool of Science, Auckland University of Technology, Auckland, New ZealandDepartment of Surgery, University of Auckland, Auckland, New ZealandAllergic rhinitis (AR) and chronic rhinosinusitis (CRS) are common respiratory conditions that significantly impact patient health and contribute to substantial healthcare burdens. While conventional treatments offer symptom relief, many patients continue to experience persistent symptoms, side effects, or resistance to standard therapies. This highlights the growing need for novel, non-invasive, and sustainable therapeutic strategies to manage chronic airway inflammation. This review examines acoustic therapy, an emerging non-pharmacological treatment that uses sound wave-induced vibrations as a potential adjunctive therapy for AR and CRS. Acoustic therapy shows potential benefits, including enhanced nitric oxide production, improved mucociliary clearance, and modulation of immune responses by activating mechanosensitive pathways and disrupting pathogenic biofilms. Preliminary clinical findings across some trials have reported improvements in peak nasal inspiratory flow ranging from approximately 17% to 31%, significant reductions in nasal congestion and symptom scores, such as Total Nasal Symptom Score, Sino-Nasal Outcome Test-22 (SNOT-22), and enhancements in sleep quality and patient-reported outcomes. Given this limited but expanding body of evidence, we integrate interdisciplinary insights from respiratory medicine, immunology, and microbiome science to provide a translational framework for future research. We highlight the need for rigorously designed clinical trials to assess acoustic therapy's therapeutic efficacy, safety, and long-term impact. As this field evolves, acoustic therapy holds significant potential to address unmet needs in chronic respiratory diseases and contributes to improved patient care.https://www.frontiersin.org/articles/10.3389/falgy.2025.1649031/fullnasal diseasevibrationallergic rhinitischronic rhinosinusitisnitric oxidenasal microbiome |
| spellingShingle | Jude Oluwapelumi Alao Kelvin E. M. Lau David White Kevin Lee Chris Puli'uvea Jim Bartley Acoustic therapy for allergic rhinitis and chronic rhinosinusitis: modulating microbiome, immunity and well-being Frontiers in Allergy nasal disease vibration allergic rhinitis chronic rhinosinusitis nitric oxide nasal microbiome |
| title | Acoustic therapy for allergic rhinitis and chronic rhinosinusitis: modulating microbiome, immunity and well-being |
| title_full | Acoustic therapy for allergic rhinitis and chronic rhinosinusitis: modulating microbiome, immunity and well-being |
| title_fullStr | Acoustic therapy for allergic rhinitis and chronic rhinosinusitis: modulating microbiome, immunity and well-being |
| title_full_unstemmed | Acoustic therapy for allergic rhinitis and chronic rhinosinusitis: modulating microbiome, immunity and well-being |
| title_short | Acoustic therapy for allergic rhinitis and chronic rhinosinusitis: modulating microbiome, immunity and well-being |
| title_sort | acoustic therapy for allergic rhinitis and chronic rhinosinusitis modulating microbiome immunity and well being |
| topic | nasal disease vibration allergic rhinitis chronic rhinosinusitis nitric oxide nasal microbiome |
| url | https://www.frontiersin.org/articles/10.3389/falgy.2025.1649031/full |
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