High Maternal Neonatal Mortality and Morbidity in Pregnancy with Eisenmenger Syndrome

Objectives. This study is aimed at evaluating the maternal and perinatal characteristics and pregnancy outcomes of ES. Material and Methods. This is a retrospective cohort study of pregnancy with Eisenmenger syndrome (ES) in Dr. Soetomo Hospital from January 2018 to December 2019. Total sampling siz...

Full description

Saved in:
Bibliographic Details
Main Authors: Erry Gumilar Dachlan, Amirah, Nareswari Cininta, Rizky Pranadyan, Alisia Yuana Putri, Yudi Her Oktaviono, Muhammad Ilham Aldika Akbar
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Journal of Pregnancy
Online Access:http://dx.doi.org/10.1155/2021/3248850
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1849413441919385600
author Erry Gumilar Dachlan
Amirah
Nareswari Cininta
Rizky Pranadyan
Alisia Yuana Putri
Yudi Her Oktaviono
Muhammad Ilham Aldika Akbar
author_facet Erry Gumilar Dachlan
Amirah
Nareswari Cininta
Rizky Pranadyan
Alisia Yuana Putri
Yudi Her Oktaviono
Muhammad Ilham Aldika Akbar
author_sort Erry Gumilar Dachlan
collection DOAJ
description Objectives. This study is aimed at evaluating the maternal and perinatal characteristics and pregnancy outcomes of ES. Material and Methods. This is a retrospective cohort study of pregnancy with Eisenmenger syndrome (ES) in Dr. Soetomo Hospital from January 2018 to December 2019. Total sampling size was obtained. We collected all baseline maternal-perinatal characteristic data, cardiac status, and pregnancy outcomes as primary outcomes. The maternal death cases were also evaluated, and we compared characteristics based on defect size (< or >3 cm). Results. During study periods, we collected 18 cases with ES from a total of 152 pregnancies with heart disease. The underlying heart disease type includes atrial septal defect (ASD), ventricle septal defect (VSD), and patent ductus arteriosus (PDA). All cases suffered pulmonary hypertension (PH), 3 cases moderate, and 15 cases as severe. 94% of cases fall into heart failure (DC FC NYHA III-IV) during treatment. The majority of cases are delivered by cesarean section (88.9%). Pregnancy complications found include preterm birth (78%), low birthweight (94%), intrauterine growth restriction (55%), oligohydramnios (16%), severe preeclampsia (33%), and placenta previa (5.5%). Large defect group has an older maternal ages (30.18±4.60 vs. 24.15±2.75; p=0.002), higher clinical sign (100 vs. 40%, p=0.003), and higher preterm delivery rate (100% vs. 69%, p=0.047) compared to small defect groups. The R to L or bidirectional shunt is significantly higher at the large defect group (13 vs. 5 cases, p=0.006, 95% confidence interval: -1.156 to -0.228). There were seven maternal death cases caused by shock cardiogenic. Conclusions. Pregnancy with ES is still associated with very high maternal neonatal mortality and morbidity. The larger defect size is correlated with clinical performances and pregnancy outcomes. Effective preconception counseling is the best strategy to reduce the risk of maternal and neonatal death in ES women.
format Article
id doaj-art-6f863c5d3da446c8ab1ac76f9acc080b
institution Kabale University
issn 2090-2727
2090-2735
language English
publishDate 2021-01-01
publisher Wiley
record_format Article
series Journal of Pregnancy
spelling doaj-art-6f863c5d3da446c8ab1ac76f9acc080b2025-08-20T03:34:05ZengWileyJournal of Pregnancy2090-27272090-27352021-01-01202110.1155/2021/32488503248850High Maternal Neonatal Mortality and Morbidity in Pregnancy with Eisenmenger SyndromeErry Gumilar Dachlan0Amirah1Nareswari Cininta2Rizky Pranadyan3Alisia Yuana Putri4Yudi Her Oktaviono5Muhammad Ilham Aldika Akbar6Department Obstetrics & Gynecology Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaDepartment Obstetrics & Gynecology Fakfak General Hospital, West Papua, IndonesiaDepartment Obstetrics & Gynecology Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaDepartment Obstetrics & Gynecology Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaDepartment Cardiology Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaDepartment Cardiology Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaDepartment Obstetrics & Gynecology Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaObjectives. This study is aimed at evaluating the maternal and perinatal characteristics and pregnancy outcomes of ES. Material and Methods. This is a retrospective cohort study of pregnancy with Eisenmenger syndrome (ES) in Dr. Soetomo Hospital from January 2018 to December 2019. Total sampling size was obtained. We collected all baseline maternal-perinatal characteristic data, cardiac status, and pregnancy outcomes as primary outcomes. The maternal death cases were also evaluated, and we compared characteristics based on defect size (< or >3 cm). Results. During study periods, we collected 18 cases with ES from a total of 152 pregnancies with heart disease. The underlying heart disease type includes atrial septal defect (ASD), ventricle septal defect (VSD), and patent ductus arteriosus (PDA). All cases suffered pulmonary hypertension (PH), 3 cases moderate, and 15 cases as severe. 94% of cases fall into heart failure (DC FC NYHA III-IV) during treatment. The majority of cases are delivered by cesarean section (88.9%). Pregnancy complications found include preterm birth (78%), low birthweight (94%), intrauterine growth restriction (55%), oligohydramnios (16%), severe preeclampsia (33%), and placenta previa (5.5%). Large defect group has an older maternal ages (30.18±4.60 vs. 24.15±2.75; p=0.002), higher clinical sign (100 vs. 40%, p=0.003), and higher preterm delivery rate (100% vs. 69%, p=0.047) compared to small defect groups. The R to L or bidirectional shunt is significantly higher at the large defect group (13 vs. 5 cases, p=0.006, 95% confidence interval: -1.156 to -0.228). There were seven maternal death cases caused by shock cardiogenic. Conclusions. Pregnancy with ES is still associated with very high maternal neonatal mortality and morbidity. The larger defect size is correlated with clinical performances and pregnancy outcomes. Effective preconception counseling is the best strategy to reduce the risk of maternal and neonatal death in ES women.http://dx.doi.org/10.1155/2021/3248850
spellingShingle Erry Gumilar Dachlan
Amirah
Nareswari Cininta
Rizky Pranadyan
Alisia Yuana Putri
Yudi Her Oktaviono
Muhammad Ilham Aldika Akbar
High Maternal Neonatal Mortality and Morbidity in Pregnancy with Eisenmenger Syndrome
Journal of Pregnancy
title High Maternal Neonatal Mortality and Morbidity in Pregnancy with Eisenmenger Syndrome
title_full High Maternal Neonatal Mortality and Morbidity in Pregnancy with Eisenmenger Syndrome
title_fullStr High Maternal Neonatal Mortality and Morbidity in Pregnancy with Eisenmenger Syndrome
title_full_unstemmed High Maternal Neonatal Mortality and Morbidity in Pregnancy with Eisenmenger Syndrome
title_short High Maternal Neonatal Mortality and Morbidity in Pregnancy with Eisenmenger Syndrome
title_sort high maternal neonatal mortality and morbidity in pregnancy with eisenmenger syndrome
url http://dx.doi.org/10.1155/2021/3248850
work_keys_str_mv AT errygumilardachlan highmaternalneonatalmortalityandmorbidityinpregnancywitheisenmengersyndrome
AT amirah highmaternalneonatalmortalityandmorbidityinpregnancywitheisenmengersyndrome
AT nareswaricininta highmaternalneonatalmortalityandmorbidityinpregnancywitheisenmengersyndrome
AT rizkypranadyan highmaternalneonatalmortalityandmorbidityinpregnancywitheisenmengersyndrome
AT alisiayuanaputri highmaternalneonatalmortalityandmorbidityinpregnancywitheisenmengersyndrome
AT yudiheroktaviono highmaternalneonatalmortalityandmorbidityinpregnancywitheisenmengersyndrome
AT muhammadilhamaldikaakbar highmaternalneonatalmortalityandmorbidityinpregnancywitheisenmengersyndrome