The All-Cause Mortality and a Screening Tool to Determine High-Risk Patients among Prevalent Type 2 Diabetes Mellitus Patients

Aims. This study aims to determine the all-cause mortality and the associated risk factors for all-cause mortality among the prevalent type 2 diabetes mellitus (T2DM) patients within five years’ period and to develop a screening tool to determine high-risk patients. Methods. This is a cohort study o...

Full description

Saved in:
Bibliographic Details
Main Authors: Mohamad Adam Bujang, Pei Xuan Kuan, Xun Ting Tiong, Fatin Ellisya Saperi, Mastura Ismail, Feisul Idzwan Mustafa, Abd Muneer Abd Hamid
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2018/4638327
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832545790620336128
author Mohamad Adam Bujang
Pei Xuan Kuan
Xun Ting Tiong
Fatin Ellisya Saperi
Mastura Ismail
Feisul Idzwan Mustafa
Abd Muneer Abd Hamid
author_facet Mohamad Adam Bujang
Pei Xuan Kuan
Xun Ting Tiong
Fatin Ellisya Saperi
Mastura Ismail
Feisul Idzwan Mustafa
Abd Muneer Abd Hamid
author_sort Mohamad Adam Bujang
collection DOAJ
description Aims. This study aims to determine the all-cause mortality and the associated risk factors for all-cause mortality among the prevalent type 2 diabetes mellitus (T2DM) patients within five years’ period and to develop a screening tool to determine high-risk patients. Methods. This is a cohort study of T2DM patients in the national diabetes registry, Malaysia. Patients’ particulars were derived from the database between 1st January 2009 and 31st December 2009. Their records were matched with the national death record at the end of year 2013 to determine the status after five years. The factors associated with mortality were investigated, and a prognostic model was developed based on logistic regression model. Results. There were 69,555 records analyzed. The mortality rate was 1.4 persons per 100 person-years. The major cause of death were diseases of the circulatory system (28.4%), infectious and parasitic diseases (19.7%), and respiratory system (16.0%). The risk factors of mortality within five years were age group (p<0.001), body mass index category (p<0.001), duration of diabetes (p<0.001), retinopathy (p=0.001), ischaemic heart disease (p<0.001), cerebrovascular (p=0.007), nephropathy (p=0.001), and foot problem (p=0.001). The sensitivity and specificity of the proposed model was fairly strong with 70.2% and 61.3%, respectively. Conclusions. The elderly and underweight T2DM patients with complications have higher risk for mortality within five years. The model has moderate accuracy; the prognostic model can be used as a screening tool to classify T2DM patients who are at higher risk for mortality within five years.
format Article
id doaj-art-6f83d204401a4e30883f0c70906f92d9
institution Kabale University
issn 2314-6745
2314-6753
language English
publishDate 2018-01-01
publisher Wiley
record_format Article
series Journal of Diabetes Research
spelling doaj-art-6f83d204401a4e30883f0c70906f92d92025-02-03T07:24:42ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/46383274638327The All-Cause Mortality and a Screening Tool to Determine High-Risk Patients among Prevalent Type 2 Diabetes Mellitus PatientsMohamad Adam Bujang0Pei Xuan Kuan1Xun Ting Tiong2Fatin Ellisya Saperi3Mastura Ismail4Feisul Idzwan Mustafa5Abd Muneer Abd Hamid6Clinical Research Centre, Sarawak General Hospital, Ministry of Health, Kuching, MalaysiaClinical Research Centre, Sarawak General Hospital, Ministry of Health, Kuching, MalaysiaClinical Research Centre, Sarawak General Hospital, Ministry of Health, Kuching, MalaysiaClinical Research Centre, Sarawak General Hospital, Ministry of Health, Kuching, MalaysiaHealth Clinic Seremban 2, Ministry of Health, Seremban, MalaysiaNon-Communicable Diseases Sector, Ministry of Health, Putrajaya, MalaysiaNational Clinical Research Centre, Ministry of Health, Kuala Lumpur, MalaysiaAims. This study aims to determine the all-cause mortality and the associated risk factors for all-cause mortality among the prevalent type 2 diabetes mellitus (T2DM) patients within five years’ period and to develop a screening tool to determine high-risk patients. Methods. This is a cohort study of T2DM patients in the national diabetes registry, Malaysia. Patients’ particulars were derived from the database between 1st January 2009 and 31st December 2009. Their records were matched with the national death record at the end of year 2013 to determine the status after five years. The factors associated with mortality were investigated, and a prognostic model was developed based on logistic regression model. Results. There were 69,555 records analyzed. The mortality rate was 1.4 persons per 100 person-years. The major cause of death were diseases of the circulatory system (28.4%), infectious and parasitic diseases (19.7%), and respiratory system (16.0%). The risk factors of mortality within five years were age group (p<0.001), body mass index category (p<0.001), duration of diabetes (p<0.001), retinopathy (p=0.001), ischaemic heart disease (p<0.001), cerebrovascular (p=0.007), nephropathy (p=0.001), and foot problem (p=0.001). The sensitivity and specificity of the proposed model was fairly strong with 70.2% and 61.3%, respectively. Conclusions. The elderly and underweight T2DM patients with complications have higher risk for mortality within five years. The model has moderate accuracy; the prognostic model can be used as a screening tool to classify T2DM patients who are at higher risk for mortality within five years.http://dx.doi.org/10.1155/2018/4638327
spellingShingle Mohamad Adam Bujang
Pei Xuan Kuan
Xun Ting Tiong
Fatin Ellisya Saperi
Mastura Ismail
Feisul Idzwan Mustafa
Abd Muneer Abd Hamid
The All-Cause Mortality and a Screening Tool to Determine High-Risk Patients among Prevalent Type 2 Diabetes Mellitus Patients
Journal of Diabetes Research
title The All-Cause Mortality and a Screening Tool to Determine High-Risk Patients among Prevalent Type 2 Diabetes Mellitus Patients
title_full The All-Cause Mortality and a Screening Tool to Determine High-Risk Patients among Prevalent Type 2 Diabetes Mellitus Patients
title_fullStr The All-Cause Mortality and a Screening Tool to Determine High-Risk Patients among Prevalent Type 2 Diabetes Mellitus Patients
title_full_unstemmed The All-Cause Mortality and a Screening Tool to Determine High-Risk Patients among Prevalent Type 2 Diabetes Mellitus Patients
title_short The All-Cause Mortality and a Screening Tool to Determine High-Risk Patients among Prevalent Type 2 Diabetes Mellitus Patients
title_sort all cause mortality and a screening tool to determine high risk patients among prevalent type 2 diabetes mellitus patients
url http://dx.doi.org/10.1155/2018/4638327
work_keys_str_mv AT mohamadadambujang theallcausemortalityandascreeningtooltodeterminehighriskpatientsamongprevalenttype2diabetesmellituspatients
AT peixuankuan theallcausemortalityandascreeningtooltodeterminehighriskpatientsamongprevalenttype2diabetesmellituspatients
AT xuntingtiong theallcausemortalityandascreeningtooltodeterminehighriskpatientsamongprevalenttype2diabetesmellituspatients
AT fatinellisyasaperi theallcausemortalityandascreeningtooltodeterminehighriskpatientsamongprevalenttype2diabetesmellituspatients
AT masturaismail theallcausemortalityandascreeningtooltodeterminehighriskpatientsamongprevalenttype2diabetesmellituspatients
AT feisulidzwanmustafa theallcausemortalityandascreeningtooltodeterminehighriskpatientsamongprevalenttype2diabetesmellituspatients
AT abdmuneerabdhamid theallcausemortalityandascreeningtooltodeterminehighriskpatientsamongprevalenttype2diabetesmellituspatients
AT mohamadadambujang allcausemortalityandascreeningtooltodeterminehighriskpatientsamongprevalenttype2diabetesmellituspatients
AT peixuankuan allcausemortalityandascreeningtooltodeterminehighriskpatientsamongprevalenttype2diabetesmellituspatients
AT xuntingtiong allcausemortalityandascreeningtooltodeterminehighriskpatientsamongprevalenttype2diabetesmellituspatients
AT fatinellisyasaperi allcausemortalityandascreeningtooltodeterminehighriskpatientsamongprevalenttype2diabetesmellituspatients
AT masturaismail allcausemortalityandascreeningtooltodeterminehighriskpatientsamongprevalenttype2diabetesmellituspatients
AT feisulidzwanmustafa allcausemortalityandascreeningtooltodeterminehighriskpatientsamongprevalenttype2diabetesmellituspatients
AT abdmuneerabdhamid allcausemortalityandascreeningtooltodeterminehighriskpatientsamongprevalenttype2diabetesmellituspatients