Efficient Synthesis of High-Active Myoglobin and Hemoglobin by Reconstructing the Mitochondrial Heme Synthetic Pathway in Engineered <i>Saccharomyces cerevisiae</i>

Efficient Synthesis of High-Active Myoglobin and Hemoglobin by Reconstructing the Mitochondrial Heme Synthetic Pathway in Engineered <i>Saccharomyces cerevisiae</i>

Currently, various types of myoglobins and hemoglobins are widely used in the fields of food additives and biocatalytic applications. However, the limited availability of heme constrains the biosynthesis of these high-activity hemoproteins in microbial chassis cells. In this work, a new heme synthet...

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Bibliographic Details
Main Authors: Xiaoyan Sun, Yunpeng Wang, Yijie Wang, Jingwen Zhou, Jianghua Li, Jian Chen, Guocheng Du, Xinrui Zhao
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Fermentation
Subjects:
hemoproteins
mitochondrial heme synthetic pathway
spatial isolation
mitochondrial ALA transporters
<i>Saccharomyces cerevisiae</i>
Online Access:https://www.mdpi.com/2311-5637/11/5/246
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