A Novel Cause of Bowel Obstruction in a Patient with Long-Standing Crohn’s Disease
Solitary fibrous tumors are rare tumors of mesenchymal origin. Although most often observed in the lung pleura, they have been reported in varied extrapleural sites. A 70-year-old male with complicated Crohn’s disease presented with 3 days of nausea, emesis, constipation, and abdominal pain. Compute...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2021/3278392 |
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| author | Satya V. Vedula T. Paul Nickerson Douglas J. Grider |
| author_facet | Satya V. Vedula T. Paul Nickerson Douglas J. Grider |
| author_sort | Satya V. Vedula |
| collection | DOAJ |
| description | Solitary fibrous tumors are rare tumors of mesenchymal origin. Although most often observed in the lung pleura, they have been reported in varied extrapleural sites. A 70-year-old male with complicated Crohn’s disease presented with 3 days of nausea, emesis, constipation, and abdominal pain. Computed Tomography (CT) demonstrated mucosal thickening of the middescending colon, consistent with fibrosing stricture. Surgical excision revealed an unusual, 5 cm mass originating in the subserosa. Histopathology of the lesion was notable for a proliferation of cells with spindle and stellate-shaped nuclei and no appreciable mitotic figures, which extended into the muscularis and submucosa. Immunohistochemistry was STAT6 nuclear positive and cytoplasmic CD34 positive, diagnostic for solitary fibrous tumor (SFT). In this case, the SFT infiltrating into the muscularis propria and subserosa caused the stricture and bowel obstruction. This illustrates that while fibrosing strictures are usually the etiology of bowel obstruction in the setting of Crohn’s disease, other rare possible causes should be considered. |
| format | Article |
| id | doaj-art-6f82b42353bf4aa3afc3da76bc66fc23 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-6f82b42353bf4aa3afc3da76bc66fc232025-02-03T01:27:06ZengWileyCase Reports in Pathology2090-67812090-679X2021-01-01202110.1155/2021/32783923278392A Novel Cause of Bowel Obstruction in a Patient with Long-Standing Crohn’s DiseaseSatya V. Vedula0T. Paul Nickerson1Douglas J. Grider2Virginia Tech Carilion School of Medicine, 2 Riverside Circle, Roanoke, VA, USADepartment of Surgery, Section of Colorectal Surgery, Virginia Tech Carilion School of Medicine, 2 Riverside Circle, Roanoke, VA, USADepartment of Basic Science Education, Virginia Tech Carilion School of Medicine, 2 Riverside Circle, Roanoke, VA, USASolitary fibrous tumors are rare tumors of mesenchymal origin. Although most often observed in the lung pleura, they have been reported in varied extrapleural sites. A 70-year-old male with complicated Crohn’s disease presented with 3 days of nausea, emesis, constipation, and abdominal pain. Computed Tomography (CT) demonstrated mucosal thickening of the middescending colon, consistent with fibrosing stricture. Surgical excision revealed an unusual, 5 cm mass originating in the subserosa. Histopathology of the lesion was notable for a proliferation of cells with spindle and stellate-shaped nuclei and no appreciable mitotic figures, which extended into the muscularis and submucosa. Immunohistochemistry was STAT6 nuclear positive and cytoplasmic CD34 positive, diagnostic for solitary fibrous tumor (SFT). In this case, the SFT infiltrating into the muscularis propria and subserosa caused the stricture and bowel obstruction. This illustrates that while fibrosing strictures are usually the etiology of bowel obstruction in the setting of Crohn’s disease, other rare possible causes should be considered.http://dx.doi.org/10.1155/2021/3278392 |
| spellingShingle | Satya V. Vedula T. Paul Nickerson Douglas J. Grider A Novel Cause of Bowel Obstruction in a Patient with Long-Standing Crohn’s Disease Case Reports in Pathology |
| title | A Novel Cause of Bowel Obstruction in a Patient with Long-Standing Crohn’s Disease |
| title_full | A Novel Cause of Bowel Obstruction in a Patient with Long-Standing Crohn’s Disease |
| title_fullStr | A Novel Cause of Bowel Obstruction in a Patient with Long-Standing Crohn’s Disease |
| title_full_unstemmed | A Novel Cause of Bowel Obstruction in a Patient with Long-Standing Crohn’s Disease |
| title_short | A Novel Cause of Bowel Obstruction in a Patient with Long-Standing Crohn’s Disease |
| title_sort | novel cause of bowel obstruction in a patient with long standing crohn s disease |
| url | http://dx.doi.org/10.1155/2021/3278392 |
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