CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma

CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma

Abstract CCN1 is a matricellular protein highly expressed in esophageal squamous cell carcinoma (ESCC) but hardly detectable in esophageal adenocarcinoma (EAC). Expression of CCN1 in EAC cells leads to TRAIL-mediated apoptosis. Unlike TRAIL, which primarily triggers cell death, APRIL and BAFF promot...

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Bibliographic Details
Main Authors: Lingling Xing, Zhenyu Jiang, Ruize Xu, Tong Dang, Jinbao Wu, Jianyuan Chai, Xianmei Meng
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Esophageal cancer
CCN1
APRIL
BAFF
BCMA
Furin
Online Access:https://doi.org/10.1038/s41598-025-86228-z
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