Endogenous Galectin-8 protects against Th17 infiltration and fibrosis following acute kidney injury

Endogenous Galectin-8 protects against Th17 infiltration and fibrosis following acute kidney injury

Abstract Background Acute kidney injury (AKI) is a serious clinical condition characterized by a rapid decline in renal function, often progressing to chronic kidney disease (CKD) and fibrosis. The endogenous mechanisms influencing kidney injury resolution or maladaptive repair remain poorly underst...

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Main Authors: Elisa Perez-Moreno, Adely de la Peña, Tomás Toledo, Javiera Saez, Francisca Pérez-Molina, Sofía Espinoza, Claudia Metz, Nicole Díaz-Valdivia, Lorena Azócar, Carolina Prado, Rodrigo Pacheco, Fabian Segovia-Miranda, Alejandro S. Godoy, Cristian A. Amador, Teo Feuerhake, Alfonso González, Andrea Soza
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Medicine
Subjects:
Galectin-8
Acute kidney injury
AKI
Fibrosis
Chronic kidney disease
CDK
Online Access:https://doi.org/10.1186/s10020-025-01245-y
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