Photobiomodulation for Cobalt Chloride-Induced Hypoxic Damage of RF/6A Cells by 670 nm Light-Emitting Diode Irradiation
Objective. The goal of this study was to investigate the therapeutic efficacy of 670 nm light-emitting diode (LED) irradiation on the diabetic retinopathy (DR) using hypoxic rhesus monkey choroid-retinal (RF/6A) cells as the model system. Background Data. Treatment with light in the spectrum from re...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | International Journal of Photoenergy |
| Online Access: | http://dx.doi.org/10.1155/2014/971491 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849413489930534912 |
|---|---|
| author | Shuang Li Qiang-Li Wang Xin Chen Xian-qiang Mi |
| author_facet | Shuang Li Qiang-Li Wang Xin Chen Xian-qiang Mi |
| author_sort | Shuang Li |
| collection | DOAJ |
| description | Objective. The goal of this study was to investigate the therapeutic efficacy of 670 nm light-emitting diode (LED) irradiation on the diabetic retinopathy (DR) using hypoxic rhesus monkey choroid-retinal (RF/6A) cells as the model system. Background Data. Treatment with light in the spectrum from red to near-infrared region has beneficial effect on tissue injury and 670 nm LED is currently under clinical investigation for retinoprotective therapy. Methods. Studies were conducted in the cultured cells under hypoxia treated by cobalt chloride (CoCl2). After irradiation by 670 nm LED with different power densities, cell viability, cytochrome C oxidase activity, and ATP concentration were measured. Results. The irradiation of 670 nm LED significantly improved cell viability, cytochrome C oxidase activity, and ATP concentration in the hypoxia RF/6A cells. Conclusion. 670 nm LED irradiation could recover the hypoxia damage caused by CoCl2. Photobiomodulation of 670 nm LED plays a potential role for the treatment of diabetic retinopathy. |
| format | Article |
| id | doaj-art-6f80f1ce2aed4e4db5f045f4e1f868cf |
| institution | Kabale University |
| issn | 1110-662X 1687-529X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Photoenergy |
| spelling | doaj-art-6f80f1ce2aed4e4db5f045f4e1f868cf2025-08-20T03:34:05ZengWileyInternational Journal of Photoenergy1110-662X1687-529X2014-01-01201410.1155/2014/971491971491Photobiomodulation for Cobalt Chloride-Induced Hypoxic Damage of RF/6A Cells by 670 nm Light-Emitting Diode IrradiationShuang Li0Qiang-Li Wang1Xin Chen2Xian-qiang Mi3College of Medical Device and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaShanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaCollege of Medical Device and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaCollege of Medical Device and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaObjective. The goal of this study was to investigate the therapeutic efficacy of 670 nm light-emitting diode (LED) irradiation on the diabetic retinopathy (DR) using hypoxic rhesus monkey choroid-retinal (RF/6A) cells as the model system. Background Data. Treatment with light in the spectrum from red to near-infrared region has beneficial effect on tissue injury and 670 nm LED is currently under clinical investigation for retinoprotective therapy. Methods. Studies were conducted in the cultured cells under hypoxia treated by cobalt chloride (CoCl2). After irradiation by 670 nm LED with different power densities, cell viability, cytochrome C oxidase activity, and ATP concentration were measured. Results. The irradiation of 670 nm LED significantly improved cell viability, cytochrome C oxidase activity, and ATP concentration in the hypoxia RF/6A cells. Conclusion. 670 nm LED irradiation could recover the hypoxia damage caused by CoCl2. Photobiomodulation of 670 nm LED plays a potential role for the treatment of diabetic retinopathy.http://dx.doi.org/10.1155/2014/971491 |
| spellingShingle | Shuang Li Qiang-Li Wang Xin Chen Xian-qiang Mi Photobiomodulation for Cobalt Chloride-Induced Hypoxic Damage of RF/6A Cells by 670 nm Light-Emitting Diode Irradiation International Journal of Photoenergy |
| title | Photobiomodulation for Cobalt Chloride-Induced Hypoxic Damage of RF/6A Cells by 670 nm Light-Emitting Diode Irradiation |
| title_full | Photobiomodulation for Cobalt Chloride-Induced Hypoxic Damage of RF/6A Cells by 670 nm Light-Emitting Diode Irradiation |
| title_fullStr | Photobiomodulation for Cobalt Chloride-Induced Hypoxic Damage of RF/6A Cells by 670 nm Light-Emitting Diode Irradiation |
| title_full_unstemmed | Photobiomodulation for Cobalt Chloride-Induced Hypoxic Damage of RF/6A Cells by 670 nm Light-Emitting Diode Irradiation |
| title_short | Photobiomodulation for Cobalt Chloride-Induced Hypoxic Damage of RF/6A Cells by 670 nm Light-Emitting Diode Irradiation |
| title_sort | photobiomodulation for cobalt chloride induced hypoxic damage of rf 6a cells by 670 nm light emitting diode irradiation |
| url | http://dx.doi.org/10.1155/2014/971491 |
| work_keys_str_mv | AT shuangli photobiomodulationforcobaltchlorideinducedhypoxicdamageofrf6acellsby670nmlightemittingdiodeirradiation AT qiangliwang photobiomodulationforcobaltchlorideinducedhypoxicdamageofrf6acellsby670nmlightemittingdiodeirradiation AT xinchen photobiomodulationforcobaltchlorideinducedhypoxicdamageofrf6acellsby670nmlightemittingdiodeirradiation AT xianqiangmi photobiomodulationforcobaltchlorideinducedhypoxicdamageofrf6acellsby670nmlightemittingdiodeirradiation |