Metastatic Prostate Cancer Manifesting as Cholestatic Jaundice: A Case Report and Review of the Literature
A paraneoplastic syndrome can often present as the first manifestation of an underlying malignancy. We report a patient who presented with cholestatic jaundice as a paraneoplastic syndrome from his newly diagnosed metastatic prostate cancer. He received initial treatment with androgen deprivation th...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/1809432 |
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| _version_ | 1850222385009000448 |
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| author | Deepak Ravindranathan Emilie Elise Hitron Greta Anne Russler Yue Xue Mehmet Asim Bilen |
| author_facet | Deepak Ravindranathan Emilie Elise Hitron Greta Anne Russler Yue Xue Mehmet Asim Bilen |
| author_sort | Deepak Ravindranathan |
| collection | DOAJ |
| description | A paraneoplastic syndrome can often present as the first manifestation of an underlying malignancy. We report a patient who presented with cholestatic jaundice as a paraneoplastic syndrome from his newly diagnosed metastatic prostate cancer. He received initial treatment with androgen deprivation therapy followed by six cycles of docetaxel resulting in resolution of his cholestatic process, normalization of liver enzyme levels, and excellent biochemical and radiographic response. To the best of our knowledge, this is the first reported case of metastatic prostate cancer with cholestatic jaundice as a paraneoplastic phenomenon to be safely treated with androgen deprivation therapy and upfront docetaxel, reflecting the latest shift in the treatment of metastatic prostate cancer. |
| format | Article |
| id | doaj-art-6f7aea4cc25043ada5e014b9463cef8b |
| institution | OA Journals |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-6f7aea4cc25043ada5e014b9463cef8b2025-08-20T02:06:22ZengWileyCase Reports in Oncological Medicine2090-67062090-67142018-01-01201810.1155/2018/18094321809432Metastatic Prostate Cancer Manifesting as Cholestatic Jaundice: A Case Report and Review of the LiteratureDeepak Ravindranathan0Emilie Elise Hitron1Greta Anne Russler2Yue Xue3Mehmet Asim Bilen4Department of Medicine, Emory University School of Medicine, Atlanta, GA, USADepartment of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USADepartment of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USADepartment of Pathology, Emory University School of Medicine, Atlanta, GA, USADepartment of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USAA paraneoplastic syndrome can often present as the first manifestation of an underlying malignancy. We report a patient who presented with cholestatic jaundice as a paraneoplastic syndrome from his newly diagnosed metastatic prostate cancer. He received initial treatment with androgen deprivation therapy followed by six cycles of docetaxel resulting in resolution of his cholestatic process, normalization of liver enzyme levels, and excellent biochemical and radiographic response. To the best of our knowledge, this is the first reported case of metastatic prostate cancer with cholestatic jaundice as a paraneoplastic phenomenon to be safely treated with androgen deprivation therapy and upfront docetaxel, reflecting the latest shift in the treatment of metastatic prostate cancer.http://dx.doi.org/10.1155/2018/1809432 |
| spellingShingle | Deepak Ravindranathan Emilie Elise Hitron Greta Anne Russler Yue Xue Mehmet Asim Bilen Metastatic Prostate Cancer Manifesting as Cholestatic Jaundice: A Case Report and Review of the Literature Case Reports in Oncological Medicine |
| title | Metastatic Prostate Cancer Manifesting as Cholestatic Jaundice: A Case Report and Review of the Literature |
| title_full | Metastatic Prostate Cancer Manifesting as Cholestatic Jaundice: A Case Report and Review of the Literature |
| title_fullStr | Metastatic Prostate Cancer Manifesting as Cholestatic Jaundice: A Case Report and Review of the Literature |
| title_full_unstemmed | Metastatic Prostate Cancer Manifesting as Cholestatic Jaundice: A Case Report and Review of the Literature |
| title_short | Metastatic Prostate Cancer Manifesting as Cholestatic Jaundice: A Case Report and Review of the Literature |
| title_sort | metastatic prostate cancer manifesting as cholestatic jaundice a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2018/1809432 |
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