Multigenerational family coaggregation study of obsessive-compulsive disorder and cardiometabolic disorders
Background Obsessive-compulsive disorder (OCD) is associated with an increased risk of morbidity and mortality due to cardiometabolic disorders. Whether this association is driven by familial factors is unknown. This population-based family study explored the familial co-aggregation of OCD and cardi...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2025-01-01
|
| Series: | BMJ Mental Health |
| Online Access: | https://mentalhealth.bmj.com/content/28/1/e301323.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832592647434272768 |
|---|---|
| author | David Mataix-Cols Christian Rück Lorena Fernández de la Cruz Kayoko Isomura Henrik Larsson Paul Lichtenstein Brian M D’Onofrio Anna Sidorchuk Zheng Chang James J Crowley Ralf Kuja-Halkola Isabell Brikell Josep Pol-Fuster Anna Holmberg Lina Martinsson |
| author_facet | David Mataix-Cols Christian Rück Lorena Fernández de la Cruz Kayoko Isomura Henrik Larsson Paul Lichtenstein Brian M D’Onofrio Anna Sidorchuk Zheng Chang James J Crowley Ralf Kuja-Halkola Isabell Brikell Josep Pol-Fuster Anna Holmberg Lina Martinsson |
| author_sort | David Mataix-Cols |
| collection | DOAJ |
| description | Background Obsessive-compulsive disorder (OCD) is associated with an increased risk of morbidity and mortality due to cardiometabolic disorders. Whether this association is driven by familial factors is unknown. This population-based family study explored the familial co-aggregation of OCD and cardiometabolic disorders.Methods We identified 6 049 717 individuals born in Sweden between 1950 and 2008, including 50 212 individuals with OCD, and followed them up to 2020. These individuals were linked to their mothers, fathers, full siblings, maternal and paternal half siblings, aunts, uncles and cousins. We estimated the risk of cardiovascular diseases (CVD) and metabolic disorders (including obesity, type 2 diabetes and hyperlipidaemia), comparing the relatives of probands with and without OCD. Cox proportional hazards regression models, incorporating time-varying exposures, estimated HRs.Results OCD was associated with an increased risk of CVD (HR 1.47; 95% CI 1.43 to 1.51), obesity (HR 1.69; 95% CI 1.63 to 1.74), type 2 diabetes (HR 2.01; 95% CI 1.90 to 2.12) and hyperlipidaemia (HR 1.42; 95% CI 1.33 to 1.52). The relatives of probands with OCD exhibited small increased risks of CVD (HRs from 1.01 to 1.11) and obesity (HRs from 1.03 to 1.20). Slightly increased risks for type 2 diabetes were observed in mothers (HR 1.11; 95% CI 1.07 to 1.15) and full siblings (HR 1.12; 95% CI 1.05 to 1.20), while for hyperlipidaemia it was only observed in mothers (HR 1.06; 95% CI 1.02 to 1.10).Conclusions Our results do not support a major contribution of familial factors to the association between OCD and cardiometabolic disorders, suggesting a more prominent role of unique environmental factors. |
| format | Article |
| id | doaj-art-6f76758255cf4fbda4b7a750e7ba6f14 |
| institution | Kabale University |
| issn | 2755-9734 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Mental Health |
| spelling | doaj-art-6f76758255cf4fbda4b7a750e7ba6f142025-01-21T06:25:09ZengBMJ Publishing GroupBMJ Mental Health2755-97342025-01-0128110.1136/bmjment-2024-301323Multigenerational family coaggregation study of obsessive-compulsive disorder and cardiometabolic disordersDavid Mataix-Cols0Christian Rück1Lorena Fernández de la Cruz2Kayoko Isomura3Henrik Larsson4Paul Lichtenstein5Brian M D’Onofrio6Anna Sidorchuk7Zheng Chang8James J Crowley9Ralf Kuja-Halkola10Isabell Brikell11Josep Pol-Fuster12Anna Holmberg13Lina Martinsson14Department of Clinical Sciences, Lund University, Lund, SwedenCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, SwedenCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, SwedenCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, SwedenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, SwedenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, SwedenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, SwedenCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, SwedenCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, SwedenBackground Obsessive-compulsive disorder (OCD) is associated with an increased risk of morbidity and mortality due to cardiometabolic disorders. Whether this association is driven by familial factors is unknown. This population-based family study explored the familial co-aggregation of OCD and cardiometabolic disorders.Methods We identified 6 049 717 individuals born in Sweden between 1950 and 2008, including 50 212 individuals with OCD, and followed them up to 2020. These individuals were linked to their mothers, fathers, full siblings, maternal and paternal half siblings, aunts, uncles and cousins. We estimated the risk of cardiovascular diseases (CVD) and metabolic disorders (including obesity, type 2 diabetes and hyperlipidaemia), comparing the relatives of probands with and without OCD. Cox proportional hazards regression models, incorporating time-varying exposures, estimated HRs.Results OCD was associated with an increased risk of CVD (HR 1.47; 95% CI 1.43 to 1.51), obesity (HR 1.69; 95% CI 1.63 to 1.74), type 2 diabetes (HR 2.01; 95% CI 1.90 to 2.12) and hyperlipidaemia (HR 1.42; 95% CI 1.33 to 1.52). The relatives of probands with OCD exhibited small increased risks of CVD (HRs from 1.01 to 1.11) and obesity (HRs from 1.03 to 1.20). Slightly increased risks for type 2 diabetes were observed in mothers (HR 1.11; 95% CI 1.07 to 1.15) and full siblings (HR 1.12; 95% CI 1.05 to 1.20), while for hyperlipidaemia it was only observed in mothers (HR 1.06; 95% CI 1.02 to 1.10).Conclusions Our results do not support a major contribution of familial factors to the association between OCD and cardiometabolic disorders, suggesting a more prominent role of unique environmental factors.https://mentalhealth.bmj.com/content/28/1/e301323.full |
| spellingShingle | David Mataix-Cols Christian Rück Lorena Fernández de la Cruz Kayoko Isomura Henrik Larsson Paul Lichtenstein Brian M D’Onofrio Anna Sidorchuk Zheng Chang James J Crowley Ralf Kuja-Halkola Isabell Brikell Josep Pol-Fuster Anna Holmberg Lina Martinsson Multigenerational family coaggregation study of obsessive-compulsive disorder and cardiometabolic disorders BMJ Mental Health |
| title | Multigenerational family coaggregation study of obsessive-compulsive disorder and cardiometabolic disorders |
| title_full | Multigenerational family coaggregation study of obsessive-compulsive disorder and cardiometabolic disorders |
| title_fullStr | Multigenerational family coaggregation study of obsessive-compulsive disorder and cardiometabolic disorders |
| title_full_unstemmed | Multigenerational family coaggregation study of obsessive-compulsive disorder and cardiometabolic disorders |
| title_short | Multigenerational family coaggregation study of obsessive-compulsive disorder and cardiometabolic disorders |
| title_sort | multigenerational family coaggregation study of obsessive compulsive disorder and cardiometabolic disorders |
| url | https://mentalhealth.bmj.com/content/28/1/e301323.full |
| work_keys_str_mv | AT davidmataixcols multigenerationalfamilycoaggregationstudyofobsessivecompulsivedisorderandcardiometabolicdisorders AT christianruck multigenerationalfamilycoaggregationstudyofobsessivecompulsivedisorderandcardiometabolicdisorders AT lorenafernandezdelacruz multigenerationalfamilycoaggregationstudyofobsessivecompulsivedisorderandcardiometabolicdisorders AT kayokoisomura multigenerationalfamilycoaggregationstudyofobsessivecompulsivedisorderandcardiometabolicdisorders AT henriklarsson multigenerationalfamilycoaggregationstudyofobsessivecompulsivedisorderandcardiometabolicdisorders AT paullichtenstein multigenerationalfamilycoaggregationstudyofobsessivecompulsivedisorderandcardiometabolicdisorders AT brianmdonofrio multigenerationalfamilycoaggregationstudyofobsessivecompulsivedisorderandcardiometabolicdisorders AT annasidorchuk multigenerationalfamilycoaggregationstudyofobsessivecompulsivedisorderandcardiometabolicdisorders AT zhengchang multigenerationalfamilycoaggregationstudyofobsessivecompulsivedisorderandcardiometabolicdisorders AT jamesjcrowley multigenerationalfamilycoaggregationstudyofobsessivecompulsivedisorderandcardiometabolicdisorders AT ralfkujahalkola multigenerationalfamilycoaggregationstudyofobsessivecompulsivedisorderandcardiometabolicdisorders AT isabellbrikell multigenerationalfamilycoaggregationstudyofobsessivecompulsivedisorderandcardiometabolicdisorders AT joseppolfuster multigenerationalfamilycoaggregationstudyofobsessivecompulsivedisorderandcardiometabolicdisorders AT annaholmberg multigenerationalfamilycoaggregationstudyofobsessivecompulsivedisorderandcardiometabolicdisorders AT linamartinsson multigenerationalfamilycoaggregationstudyofobsessivecompulsivedisorderandcardiometabolicdisorders |