The pivotal role of von Willebrand factor binding to platelet αIIbβ3 in stabilizing the formation of a platelet plug at sites of injury

The pivotal role of von Willebrand factor binding to platelet αIIbβ3 in stabilizing the formation of a platelet plug at sites of injury

The interaction between VWF and platelet αIIbβ3 is thought to be essential for clot formation at injury sites, but its biological properties remain poorly understood due to the complexity and overlap with other αIIbβ3 ligands. Here, we developed a novel binding assay using a recombinant αIIbβ3 head...

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Bibliographic Details
Main Authors: Qizhen Shi, Jeremy G. Mattson, Patricia A. Morateck, Pamela A. Christopherson, Jocelyn A. Schroeder, Scot A. Fahs, Jessica Rapten, Marie L. Schulte, Hartmut Weiler, Jieqing Zhu, Sandra L. Haberichter, Veronica H. Flood, Robert R. Montgomery
Format: Article
Language:English
Published: Ferrata Storti Foundation 2025-05-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/12077
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