Anti-inflammatory effects of Stephania tetrandra S. Moore on interleukin-6 production and experimental inflammatory disease models
Deregulation of interleukin-6 (IL-6) expression caused the synthesis and release of many inflammatory mediators. It is involved in chronic inflammation, autoimmune diseases, and malignancy. Stephania tetrandra S. Moore is a Chinese medicinal herb which has been used traditionary as a remedy for neur...
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| Format: | Article |
| Language: | English |
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Wiley
1996-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935196000415 |
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| author | H-S. Kang Y-H. Kim C-S. Lee J-J. Lee I. Choi K-H. Pyun |
| author_facet | H-S. Kang Y-H. Kim C-S. Lee J-J. Lee I. Choi K-H. Pyun |
| author_sort | H-S. Kang |
| collection | DOAJ |
| description | Deregulation of interleukin-6 (IL-6) expression caused the synthesis and release of many inflammatory mediators. It is involved in chronic inflammation, autoimmune diseases, and malignancy. Stephania tetrandra S. Moore is a Chinese medicinal herb which has been used traditionary as a remedy for neuralgia and arthritis in China. To investigate the anti-inflammatory effects of S. tetrandra S. Moore in vitro and in vivo, its effects on the production of IL-6 and inflammatory mediators were analysed. When human monocytes/macrophages stimulated with silica were treated with 0.1–10 μg/ml S. tetranda S. Moore, the production of IL-6 was inhibited up to 50%. At these concentrations, it had no cytotoxicity effect on these cells. It also suppressed the production of IL-6 by alveolar macrophages stimulated with silica. In addition, it inhibited the release of superoxide anion and hydrogen peroxide from human monocytes/macrophages. To assess the anti-fibrosis effects of S. tetrandra S. Moore, its effects on in vivo experimental inflammatory models were evaluated. In the experimental silicosis model, IL-6 activities in the sera and in the culture supernatants of pulmonary fibroblasts were also inhibited by it. In vitro and in vivo treatment of S. tetrandra S. Moore reduced collagen production by rat lung fibroblasts and lung tissue. Also, S. tetrandra S. Moore reduced the levels of serum GOT and GPT in the rat cirrhosis model induced by CCL4, and it was effective in reducing hepatic fibrosis and nodular formation. Taken together, these data indicate that it has a potent anti-inflammatory and antifibrosis effect by reducing IL-6 production. |
| format | Article |
| id | doaj-art-6f67db74ae7744f3bb09b844c488cd49 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1996-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-6f67db74ae7744f3bb09b844c488cd492025-08-20T02:06:22ZengWileyMediators of Inflammation0962-93511466-18611996-01-015428029110.1155/S0962935196000415Anti-inflammatory effects of Stephania tetrandra S. Moore on interleukin-6 production and experimental inflammatory disease modelsH-S. Kang0Y-H. Kim1C-S. Lee2J-J. Lee3I. Choi4K-H. Pyun5Immune Cell Signal Transduction R.U., Korea Research Institute of Bioscience and Biotechnology, KIST, Yusong, P.O. Box 115, Taejon 305-600, KoreaImmune Cell Signal Transduction R.U., Korea Research Institute of Bioscience and Biotechnology, KIST, Yusong, P.O. Box 115, Taejon 305-600, KoreaDepartment of Pathology, School of Medicine, Chungnam University, Taejon, KoreaImmune Cell Signal Transduction R.U., Korea Research Institute of Bioscience and Biotechnology, KIST, Yusong, P.O. Box 115, Taejon 305-600, KoreaImmune Cell Signal Transduction R.U., Korea Research Institute of Bioscience and Biotechnology, KIST, Yusong, P.O. Box 115, Taejon 305-600, KoreaImmune Cell Signal Transduction R.U., Korea Research Institute of Bioscience and Biotechnology, KIST, Yusong, P.O. Box 115, Taejon 305-600, KoreaDeregulation of interleukin-6 (IL-6) expression caused the synthesis and release of many inflammatory mediators. It is involved in chronic inflammation, autoimmune diseases, and malignancy. Stephania tetrandra S. Moore is a Chinese medicinal herb which has been used traditionary as a remedy for neuralgia and arthritis in China. To investigate the anti-inflammatory effects of S. tetrandra S. Moore in vitro and in vivo, its effects on the production of IL-6 and inflammatory mediators were analysed. When human monocytes/macrophages stimulated with silica were treated with 0.1–10 μg/ml S. tetranda S. Moore, the production of IL-6 was inhibited up to 50%. At these concentrations, it had no cytotoxicity effect on these cells. It also suppressed the production of IL-6 by alveolar macrophages stimulated with silica. In addition, it inhibited the release of superoxide anion and hydrogen peroxide from human monocytes/macrophages. To assess the anti-fibrosis effects of S. tetrandra S. Moore, its effects on in vivo experimental inflammatory models were evaluated. In the experimental silicosis model, IL-6 activities in the sera and in the culture supernatants of pulmonary fibroblasts were also inhibited by it. In vitro and in vivo treatment of S. tetrandra S. Moore reduced collagen production by rat lung fibroblasts and lung tissue. Also, S. tetrandra S. Moore reduced the levels of serum GOT and GPT in the rat cirrhosis model induced by CCL4, and it was effective in reducing hepatic fibrosis and nodular formation. Taken together, these data indicate that it has a potent anti-inflammatory and antifibrosis effect by reducing IL-6 production.http://dx.doi.org/10.1155/S0962935196000415 |
| spellingShingle | H-S. Kang Y-H. Kim C-S. Lee J-J. Lee I. Choi K-H. Pyun Anti-inflammatory effects of Stephania tetrandra S. Moore on interleukin-6 production and experimental inflammatory disease models Mediators of Inflammation |
| title | Anti-inflammatory effects of Stephania tetrandra S. Moore on interleukin-6 production and experimental inflammatory disease models |
| title_full | Anti-inflammatory effects of Stephania tetrandra S. Moore on interleukin-6 production and experimental inflammatory disease models |
| title_fullStr | Anti-inflammatory effects of Stephania tetrandra S. Moore on interleukin-6 production and experimental inflammatory disease models |
| title_full_unstemmed | Anti-inflammatory effects of Stephania tetrandra S. Moore on interleukin-6 production and experimental inflammatory disease models |
| title_short | Anti-inflammatory effects of Stephania tetrandra S. Moore on interleukin-6 production and experimental inflammatory disease models |
| title_sort | anti inflammatory effects of stephania tetrandra s moore on interleukin 6 production and experimental inflammatory disease models |
| url | http://dx.doi.org/10.1155/S0962935196000415 |
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