Pediatric deep venous thrombosis associated with Staphylococcus aureus osteomyelitis
Introduction: Our objective was to evaluate clinical features of children with deep venous thrombosis (DVT) and acute hematogenous osteomyelitis (AHO) caused by Staphylococcus aureus. Methodology: We analyzed 4 years of medical records of patients with AHO and DVT caused by Staphylococcus aureus (S...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Journal of Infection in Developing Countries
2023-04-01
|
| Series: | Journal of Infection in Developing Countries |
| Subjects: | |
| Online Access: | https://jidc.org/index.php/journal/article/view/17026 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850036675060695040 |
|---|---|
| author | Linlin Liu Lingyun Guo Zhuangzhuang Wang Qiang Wang Jinjin Zeng Tianming Chen Gang Liu |
| author_facet | Linlin Liu Lingyun Guo Zhuangzhuang Wang Qiang Wang Jinjin Zeng Tianming Chen Gang Liu |
| author_sort | Linlin Liu |
| collection | DOAJ |
| description | Introduction: Our objective was to evaluate clinical features of children with deep venous thrombosis (DVT) and acute hematogenous osteomyelitis (AHO) caused by Staphylococcus aureus.
Methodology: We analyzed 4 years of medical records of patients with AHO and DVT caused by Staphylococcus aureus (S. aureus) and compared clinical and biochemical characteristics of AHO with and without DVT, as well as patients whose DVT dissolved in ≥ 3 weeks.
Results: DVT was found in 19/87 AHO individuals (22%). The median age was 9 years (range: 0.5-15 years). 74% (14/19) patients were boys. Methicillin-susceptible Staphylococcus aureus (MSSA) was present in 58% (11/19) cases. The femoral vein and common femoral vein were the two most damaged veins (9 cases each). Anticoagulation therapy with low molecular weight heparin was given to 18 (95%) patients. Within 3 weeks of anticoagulation, 7/13 (54%) with available data had completely resolved DVT. There was no rehospitalization due to bleeding or recurrent DVT. Patients with DVT were found to be older and had increased levels of C-reactive protein, procalcitonin, D-dimer, positive blood culture, incidence of intensive care unit admission, multifocal rate, and length of hospital stay. We did not find clinical difference between patients whose DVT dissolved within 3 weeks and those with > 3 weeks.
Conclusions: Over 20% of patients with S. aureus AHO developed DVT. MSSA accounted for more than half of the cases. DVT was completely resolved in more than half of the cases after 3 weeks of anticoagulant medication, with no sequelae.
|
| format | Article |
| id | doaj-art-6f60fbe84c1d47b4afb3882ca6fee7d6 |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-6f60fbe84c1d47b4afb3882ca6fee7d62025-08-20T02:57:04ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802023-04-01170410.3855/jidc.17026Pediatric deep venous thrombosis associated with Staphylococcus aureus osteomyelitisLinlin Liu0Lingyun Guo1Zhuangzhuang Wang2Qiang Wang3Jinjin Zeng4Tianming Chen5Gang Liu6Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaKey Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaKey Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaKey Laboratory of Major Diseases in Children, Ministry of Education, Department of Orthopedics, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaKey Laboratory of Major Diseases in Children, Ministry of Education, Department of Radiology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaKey Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaKey Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaIntroduction: Our objective was to evaluate clinical features of children with deep venous thrombosis (DVT) and acute hematogenous osteomyelitis (AHO) caused by Staphylococcus aureus. Methodology: We analyzed 4 years of medical records of patients with AHO and DVT caused by Staphylococcus aureus (S. aureus) and compared clinical and biochemical characteristics of AHO with and without DVT, as well as patients whose DVT dissolved in ≥ 3 weeks. Results: DVT was found in 19/87 AHO individuals (22%). The median age was 9 years (range: 0.5-15 years). 74% (14/19) patients were boys. Methicillin-susceptible Staphylococcus aureus (MSSA) was present in 58% (11/19) cases. The femoral vein and common femoral vein were the two most damaged veins (9 cases each). Anticoagulation therapy with low molecular weight heparin was given to 18 (95%) patients. Within 3 weeks of anticoagulation, 7/13 (54%) with available data had completely resolved DVT. There was no rehospitalization due to bleeding or recurrent DVT. Patients with DVT were found to be older and had increased levels of C-reactive protein, procalcitonin, D-dimer, positive blood culture, incidence of intensive care unit admission, multifocal rate, and length of hospital stay. We did not find clinical difference between patients whose DVT dissolved within 3 weeks and those with > 3 weeks. Conclusions: Over 20% of patients with S. aureus AHO developed DVT. MSSA accounted for more than half of the cases. DVT was completely resolved in more than half of the cases after 3 weeks of anticoagulant medication, with no sequelae. https://jidc.org/index.php/journal/article/view/17026thrombosisosteomyelitisStaphylococcus aureuschildren |
| spellingShingle | Linlin Liu Lingyun Guo Zhuangzhuang Wang Qiang Wang Jinjin Zeng Tianming Chen Gang Liu Pediatric deep venous thrombosis associated with Staphylococcus aureus osteomyelitis Journal of Infection in Developing Countries thrombosis osteomyelitis Staphylococcus aureus children |
| title | Pediatric deep venous thrombosis associated with Staphylococcus aureus osteomyelitis |
| title_full | Pediatric deep venous thrombosis associated with Staphylococcus aureus osteomyelitis |
| title_fullStr | Pediatric deep venous thrombosis associated with Staphylococcus aureus osteomyelitis |
| title_full_unstemmed | Pediatric deep venous thrombosis associated with Staphylococcus aureus osteomyelitis |
| title_short | Pediatric deep venous thrombosis associated with Staphylococcus aureus osteomyelitis |
| title_sort | pediatric deep venous thrombosis associated with staphylococcus aureus osteomyelitis |
| topic | thrombosis osteomyelitis Staphylococcus aureus children |
| url | https://jidc.org/index.php/journal/article/view/17026 |
| work_keys_str_mv | AT linlinliu pediatricdeepvenousthrombosisassociatedwithstaphylococcusaureusosteomyelitis AT lingyunguo pediatricdeepvenousthrombosisassociatedwithstaphylococcusaureusosteomyelitis AT zhuangzhuangwang pediatricdeepvenousthrombosisassociatedwithstaphylococcusaureusosteomyelitis AT qiangwang pediatricdeepvenousthrombosisassociatedwithstaphylococcusaureusosteomyelitis AT jinjinzeng pediatricdeepvenousthrombosisassociatedwithstaphylococcusaureusosteomyelitis AT tianmingchen pediatricdeepvenousthrombosisassociatedwithstaphylococcusaureusosteomyelitis AT gangliu pediatricdeepvenousthrombosisassociatedwithstaphylococcusaureusosteomyelitis |