Exercise Training Effects on Inflammatory Gene Expression in White Adipose Tissue of Young Mice
We aimed to determine the effects of 6 wks of exercise on inflammatory markers in mice concomitantly fed either high-fat (HF) or normal chow (NC) diets in young mice. C57BL/6 mice were randomized into (/group) an NC/sedentary (NC/SED), NC/exercise (NC/EX), HF/SED, and HF/EX groups. Treadmill exercis...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/767953 |
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| _version_ | 1832566763257069568 |
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| author | Tracy Baynard Victoria J. Vieira-Potter Rudy J. Valentine Jeffrey A. Woods |
| author_facet | Tracy Baynard Victoria J. Vieira-Potter Rudy J. Valentine Jeffrey A. Woods |
| author_sort | Tracy Baynard |
| collection | DOAJ |
| description | We aimed to determine the effects of 6 wks of exercise on inflammatory markers in mice concomitantly fed either high-fat (HF) or normal chow (NC) diets in young mice. C57BL/6 mice were randomized into (/group) an NC/sedentary (NC/SED), NC/exercise (NC/EX), HF/SED, and HF/EX groups. Treadmill exercise was performed 5 d/wk at 12 m/min, with 12% grade for 40 min/d. Liver triglycerides and gene expression of F4/80, MCP-1, TNF-α, leptin, and VEGF in visceral white adipose were determined. NC groups had lower body weights after 6 wks versus the HF groups ( versus g) (). F4/80 gene expression (indicator of macrophage infiltration) and liver triglycerides were greatest amongst the HF/SED group, with no differences between the remaining groups. VEGF (indicator of angiogenesis) was greatest in the HF/EX versus the other 3 groups (). Exposure of an HF diet in sedentary young mice increased visceral adipose depots and liver triglycerides versus an NC diet. Exercise training while on the HF diet protected against hepatic steatosis and possibly macrophage infiltration within white adipose tissue. This suggests that moderate exercise while on an HF diet can offer some level of protection early on in the development of obesity. |
| format | Article |
| id | doaj-art-6f5bcbfbff5344249edd2d41941b578a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-6f5bcbfbff5344249edd2d41941b578a2025-02-03T01:03:21ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/767953767953Exercise Training Effects on Inflammatory Gene Expression in White Adipose Tissue of Young MiceTracy Baynard0Victoria J. Vieira-Potter1Rudy J. Valentine2Jeffrey A. Woods3Department of Kinesiology and Nutrition, University of Illinois at Chicago, 1919 W. Taylor Street, MC-517, Chicago, IL 60612, USADepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, USADepartment of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USADepartment of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USAWe aimed to determine the effects of 6 wks of exercise on inflammatory markers in mice concomitantly fed either high-fat (HF) or normal chow (NC) diets in young mice. C57BL/6 mice were randomized into (/group) an NC/sedentary (NC/SED), NC/exercise (NC/EX), HF/SED, and HF/EX groups. Treadmill exercise was performed 5 d/wk at 12 m/min, with 12% grade for 40 min/d. Liver triglycerides and gene expression of F4/80, MCP-1, TNF-α, leptin, and VEGF in visceral white adipose were determined. NC groups had lower body weights after 6 wks versus the HF groups ( versus g) (). F4/80 gene expression (indicator of macrophage infiltration) and liver triglycerides were greatest amongst the HF/SED group, with no differences between the remaining groups. VEGF (indicator of angiogenesis) was greatest in the HF/EX versus the other 3 groups (). Exposure of an HF diet in sedentary young mice increased visceral adipose depots and liver triglycerides versus an NC diet. Exercise training while on the HF diet protected against hepatic steatosis and possibly macrophage infiltration within white adipose tissue. This suggests that moderate exercise while on an HF diet can offer some level of protection early on in the development of obesity.http://dx.doi.org/10.1155/2012/767953 |
| spellingShingle | Tracy Baynard Victoria J. Vieira-Potter Rudy J. Valentine Jeffrey A. Woods Exercise Training Effects on Inflammatory Gene Expression in White Adipose Tissue of Young Mice Mediators of Inflammation |
| title | Exercise Training Effects on Inflammatory Gene Expression in White Adipose Tissue of Young Mice |
| title_full | Exercise Training Effects on Inflammatory Gene Expression in White Adipose Tissue of Young Mice |
| title_fullStr | Exercise Training Effects on Inflammatory Gene Expression in White Adipose Tissue of Young Mice |
| title_full_unstemmed | Exercise Training Effects on Inflammatory Gene Expression in White Adipose Tissue of Young Mice |
| title_short | Exercise Training Effects on Inflammatory Gene Expression in White Adipose Tissue of Young Mice |
| title_sort | exercise training effects on inflammatory gene expression in white adipose tissue of young mice |
| url | http://dx.doi.org/10.1155/2012/767953 |
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