Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose.

Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose.

Metabolomics coupled with heavy-atom isotope-labelled glucose has been used to probe the metabolic pathways active in cultured bloodstream form trypomastigotes of Trypanosoma brucei, a parasite responsible for human African trypanosomiasis. Glucose enters many branches of metabolism beyond glycolysi...

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Main Authors: Darren J Creek, Muriel Mazet, Fiona Achcar, Jana Anderson, Dong-Hyun Kim, Ruwida Kamour, Pauline Morand, Yoann Millerioux, Marc Biran, Eduard J Kerkhoven, Achuthanunni Chokkathukalam, Stefan K Weidt, Karl E V Burgess, Rainer Breitling, David G Watson, Frédéric Bringaud, Michael P Barrett
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1004689
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https://doi.org/10.1371/journal.ppat.1004689

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