Mesenchymal stem cell-derived apoptotic vesicles regulate irritable bowel syndrome in mice via the 5-HT brain-gut axis

Abstract Background Irritable Bowel Syndrome (IBS) is a common functional gastrointestinal disorder characterized by abnormal brain-gut interactions. The pathogenic mechanisms of IBS are not fully understood, and current treatments are limited in efficacy. Aims This study aims to investigate the pot...

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Bibliographic Details
Main Authors: Ya Sun, Di Wu, Lu Lu, Jinyang Wang, Xuanyi Li, Xueli Mao, Yijun Zhang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
Online Access:https://doi.org/10.1186/s13287-025-04448-6
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