Atopic dermatitis - the review
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by a disrupted epidermal barrier, immune dysregulation, and genetic predisposition. Affecting individuals across all age groups, AD presents with recurrent flare-ups and varying clinical patterns depending on age. The path...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-01-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/56851 |
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| author | Joanna Wrona Aleksandra Kaźmierczyk Jędrzej Kęsik Daria Madycka Kacper Michta Małgorzata Słaboń Aleksandra Wójcik Karol Stępniak Wiktor Telega Kinga Wnuczek |
| author_facet | Joanna Wrona Aleksandra Kaźmierczyk Jędrzej Kęsik Daria Madycka Kacper Michta Małgorzata Słaboń Aleksandra Wójcik Karol Stępniak Wiktor Telega Kinga Wnuczek |
| author_sort | Joanna Wrona |
| collection | DOAJ |
| description |
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by a disrupted epidermal barrier, immune dysregulation, and genetic predisposition. Affecting individuals across all age groups, AD presents with recurrent flare-ups and varying clinical patterns depending on age. The pathophysiology involves key elements such as loss-of-function mutations in the filaggrin (FLG) gene, overproduction of cytokines like IL-4 and IL-13, and skin colonization by Staphylococcus aureus. Management strategies include patient education, topical therapies (e.g., corticosteroids, calcineurin inhibitors, crisaborole, and tapinarof), systemic treatments like dupilumab and methotrexate, and phototherapy for refractory cases. Preventive measures, including breastfeeding and probiotic supplementation, offer limited benefits, emphasizing the need for individualized approaches. Innovative therapies and further research into AD pathogenesis hold promise for more effective disease control and improved quality of life for patients.
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| format | Article |
| id | doaj-art-6f4e1d3f8c7b442f93c485a725c495da |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-6f4e1d3f8c7b442f93c485a725c495da2025-01-04T08:22:28ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-01-013710.12775/QS.2025.37.56851Atopic dermatitis - the reviewJoanna Wrona0https://orcid.org/0009-0004-9267-1529Aleksandra Kaźmierczyk 1https://orcid.org/0009-0007-7283-2518Jędrzej Kęsik 2https://orcid.org/0000-0001-8317-0213Daria Madycka3https://orcid.org/0000-0001-8682-1229Kacper Michta4https://orcid.org/0000-0003-3303-4859Małgorzata Słaboń5https://orcid.org/0000-0003-1627-8878Aleksandra Wójcik6https://orcid.org/0000-0003-1669-7466Karol Stępniak7https://orcid.org/0000-0002-8134-7967Wiktor Telega8https://orcid.org/0009-0007-9805-243XKinga Wnuczek9https://orcid.org/0009-0001-6687-075X4th Clinical University Hospital in Lublin, ul. Kazimierza Jaczewskiego 8, 20-954 Lublin, Poland1st Military Clinical Hospital with the Outpatient Clinic in Lublin, al. Racławickie 23, 20-049 Lublin, Poland1st Military Clinical Hospital with the Outpatient Clinic in Lublin, al. Racławickie 23, 20-049 Lublin, PolandUniversity Clinical Hospital No. 1 in Lublin, ul. Staszica 16, 20-081 Lublin, Poland4th Clinical University Hospital in Lublin, ul. Kazimierza Jaczewskiego 8, 20-954 Lublin, Poland1st Military Clinical Hospital with the Outpatient Clinic in Lublin, al. Racławickie 23, 20-049 Lublin, Poland4th Clinical University Hospital in Lublin, ul. Kazimierza Jaczewskiego 8, 20-954 Lublin, Poland1st Military Clinical Hospital with the Outpatient Clinic in Lublin, al. Racławickie 23, 20-049 Lublin, Poland1st Military Clinical Hospital with the Outpatient Clinic in Lublin, al. Racławickie 23, 20-049 Lublin, Poland4th Clinical University Hospital in Lublin, ul. Kazimierza Jaczewskiego 8, 20-954 Lublin, Poland Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by a disrupted epidermal barrier, immune dysregulation, and genetic predisposition. Affecting individuals across all age groups, AD presents with recurrent flare-ups and varying clinical patterns depending on age. The pathophysiology involves key elements such as loss-of-function mutations in the filaggrin (FLG) gene, overproduction of cytokines like IL-4 and IL-13, and skin colonization by Staphylococcus aureus. Management strategies include patient education, topical therapies (e.g., corticosteroids, calcineurin inhibitors, crisaborole, and tapinarof), systemic treatments like dupilumab and methotrexate, and phototherapy for refractory cases. Preventive measures, including breastfeeding and probiotic supplementation, offer limited benefits, emphasizing the need for individualized approaches. Innovative therapies and further research into AD pathogenesis hold promise for more effective disease control and improved quality of life for patients. https://apcz.umk.pl/QS/article/view/56851atopic dermatitisskin disorderskin barrier dysfunctionimmune dysregulation |
| spellingShingle | Joanna Wrona Aleksandra Kaźmierczyk Jędrzej Kęsik Daria Madycka Kacper Michta Małgorzata Słaboń Aleksandra Wójcik Karol Stępniak Wiktor Telega Kinga Wnuczek Atopic dermatitis - the review Quality in Sport atopic dermatitis skin disorder skin barrier dysfunction immune dysregulation |
| title | Atopic dermatitis - the review |
| title_full | Atopic dermatitis - the review |
| title_fullStr | Atopic dermatitis - the review |
| title_full_unstemmed | Atopic dermatitis - the review |
| title_short | Atopic dermatitis - the review |
| title_sort | atopic dermatitis the review |
| topic | atopic dermatitis skin disorder skin barrier dysfunction immune dysregulation |
| url | https://apcz.umk.pl/QS/article/view/56851 |
| work_keys_str_mv | AT joannawrona atopicdermatitisthereview AT aleksandrakazmierczyk atopicdermatitisthereview AT jedrzejkesik atopicdermatitisthereview AT dariamadycka atopicdermatitisthereview AT kacpermichta atopicdermatitisthereview AT małgorzatasłabon atopicdermatitisthereview AT aleksandrawojcik atopicdermatitisthereview AT karolstepniak atopicdermatitisthereview AT wiktortelega atopicdermatitisthereview AT kingawnuczek atopicdermatitisthereview |