MUSTN1 and FABP3 interact to regulate adipogenesis and lipid deposition
Lipid deposition is related to agricultural animal production and human health, and elucidating its molecular regulatory mechanisms is a topic of interest and a challenge in current scientific research. Musculoskeletal embryonic nuclear protein 1 (MUSTN1) regulates growth and development, including...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Journal of Lipid Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227525000641 |
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| author | Yu Fu Xin Hao Jingru Nie Hongliang Zhang Peng Shang Bo Zhang Hao Zhang |
| author_facet | Yu Fu Xin Hao Jingru Nie Hongliang Zhang Peng Shang Bo Zhang Hao Zhang |
| author_sort | Yu Fu |
| collection | DOAJ |
| description | Lipid deposition is related to agricultural animal production and human health, and elucidating its molecular regulatory mechanisms is a topic of interest and a challenge in current scientific research. Musculoskeletal embryonic nuclear protein 1 (MUSTN1) regulates growth and development, including muscle tissue; however, its role in fat deposition remains unknown. Thus, our objective was to determine this role. Our new findings were as follows: MUSTN1 was highly expressed in the fat tissue of pigs with strong adipose deposition capacity; functionally, MUSTN1 promoted the proliferation and adipogenic differentiation of porcine and mouse preadipocytes. MUSTN1 knockout mice were protected against HFD-induced obesity, hepatic steatosis, and insulin resistance; and fatty acid binding protein 3 was identified as an interacting protein of MUSTN1, which facilitated preadipocyte proliferation and differentiation by activating the phosphatidylinositol 3 kinase/AKT signaling pathways. This study reveals a positive regulator for fat development, which suggests a novel approach for studying obesity and animal genetic improvement through the modulation of MUSTN1 expression. |
| format | Article |
| id | doaj-art-6f49d434dcd444448d70adeefd46d1a8 |
| institution | Kabale University |
| issn | 0022-2275 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj-art-6f49d434dcd444448d70adeefd46d1a82025-08-20T03:52:46ZengElsevierJournal of Lipid Research0022-22752025-05-0166510080410.1016/j.jlr.2025.100804MUSTN1 and FABP3 interact to regulate adipogenesis and lipid depositionYu Fu0Xin Hao1Jingru Nie2Hongliang Zhang3Peng Shang4Bo Zhang5Hao Zhang6State Key Laboratory of Animal Biotech Breeding, China Agricultural University, Beijing, China; Sanya Research Institute of Chinese Academy of Tropical Agricultural Sciences, Hainan, China; Coconut Research Institute, Chinese Academy of Tropical Agricultural Sciences, Hainan, ChinaState Key Laboratory of Animal Biotech Breeding, China Agricultural University, Beijing, China; Sanya Research Institute of Chinese Academy of Tropical Agricultural Sciences, Hainan, China; Coconut Research Institute, Chinese Academy of Tropical Agricultural Sciences, Hainan, ChinaState Key Laboratory of Animal Biotech Breeding, China Agricultural University, Beijing, ChinaCollege of Animal Science, Xizang Agricultural and Animal Husbandry College, Linzhi, ChinaCollege of Animal Science, Xizang Agricultural and Animal Husbandry College, Linzhi, ChinaState Key Laboratory of Animal Biotech Breeding, China Agricultural University, Beijing, ChinaState Key Laboratory of Animal Biotech Breeding, China Agricultural University, Beijing, China; For correspondence: Hao ZhangLipid deposition is related to agricultural animal production and human health, and elucidating its molecular regulatory mechanisms is a topic of interest and a challenge in current scientific research. Musculoskeletal embryonic nuclear protein 1 (MUSTN1) regulates growth and development, including muscle tissue; however, its role in fat deposition remains unknown. Thus, our objective was to determine this role. Our new findings were as follows: MUSTN1 was highly expressed in the fat tissue of pigs with strong adipose deposition capacity; functionally, MUSTN1 promoted the proliferation and adipogenic differentiation of porcine and mouse preadipocytes. MUSTN1 knockout mice were protected against HFD-induced obesity, hepatic steatosis, and insulin resistance; and fatty acid binding protein 3 was identified as an interacting protein of MUSTN1, which facilitated preadipocyte proliferation and differentiation by activating the phosphatidylinositol 3 kinase/AKT signaling pathways. This study reveals a positive regulator for fat development, which suggests a novel approach for studying obesity and animal genetic improvement through the modulation of MUSTN1 expression.http://www.sciencedirect.com/science/article/pii/S0022227525000641MUSTN1FABP3adipogenesislipid depositionPI3K/AKT |
| spellingShingle | Yu Fu Xin Hao Jingru Nie Hongliang Zhang Peng Shang Bo Zhang Hao Zhang MUSTN1 and FABP3 interact to regulate adipogenesis and lipid deposition Journal of Lipid Research MUSTN1 FABP3 adipogenesis lipid deposition PI3K/AKT |
| title | MUSTN1 and FABP3 interact to regulate adipogenesis and lipid deposition |
| title_full | MUSTN1 and FABP3 interact to regulate adipogenesis and lipid deposition |
| title_fullStr | MUSTN1 and FABP3 interact to regulate adipogenesis and lipid deposition |
| title_full_unstemmed | MUSTN1 and FABP3 interact to regulate adipogenesis and lipid deposition |
| title_short | MUSTN1 and FABP3 interact to regulate adipogenesis and lipid deposition |
| title_sort | mustn1 and fabp3 interact to regulate adipogenesis and lipid deposition |
| topic | MUSTN1 FABP3 adipogenesis lipid deposition PI3K/AKT |
| url | http://www.sciencedirect.com/science/article/pii/S0022227525000641 |
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