Optimizing Flexor Digitorum Profundus Tendon Repair: A Narrative Review
Zone II flexor digitorum profundus (FDP) tendon injuries are complex, and present significant challenges in hand surgery, due to the need to balance strength and flexibility during repair. Traditional suture techniques often lead to complications such as adhesions or tendon rupture, prompting the ex...
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| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/16/3/97 |
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| author | Rishith R. Mereddy Emily E. Zona Camille J. LaLiberte Aaron M. Dingle |
| author_facet | Rishith R. Mereddy Emily E. Zona Camille J. LaLiberte Aaron M. Dingle |
| author_sort | Rishith R. Mereddy |
| collection | DOAJ |
| description | Zone II flexor digitorum profundus (FDP) tendon injuries are complex, and present significant challenges in hand surgery, due to the need to balance strength and flexibility during repair. Traditional suture techniques often lead to complications such as adhesions or tendon rupture, prompting the exploration of novel strategies to improve outcomes. This review investigates the use of flexor digitorum superficialis (FDS) tendon autografts to reinforce FDP repairs, alongside the integration of biomaterials to enhance mechanical strength without sacrificing FDS tissue. Key biomaterials, including collagen–polycaprolactone (PCL) composites, are evaluated for their biocompatibility, mechanical integrity, and controlled degradation properties. Collagen-PCL emerges as a leading candidate, offering the potential to reduce adhesions and promote tendon healing. Although nanomaterials such as nanofibers and nanoparticles show promise in preventing adhesions and supporting cellular proliferation, their application remains limited by manufacturing challenges. By combining advanced repair techniques with biomaterials like collagen-PCL, this approach aims to improve surgical outcomes and minimize complications. Future research will focus on validating these findings in biological models, assessing tendon healing through imaging, and comparing the cost-effectiveness of biomaterial-enhanced repairs with traditional methods. This review underscores the potential for biomaterial-based approaches to transform FDP tendon repair. |
| format | Article |
| id | doaj-art-6f455d45feff4adcb6969e520524895c |
| institution | Kabale University |
| issn | 2079-4983 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj-art-6f455d45feff4adcb6969e520524895c2025-08-20T03:43:36ZengMDPI AGJournal of Functional Biomaterials2079-49832025-03-011639710.3390/jfb16030097Optimizing Flexor Digitorum Profundus Tendon Repair: A Narrative ReviewRishith R. Mereddy0Emily E. Zona1Camille J. LaLiberte2Aaron M. Dingle3Division of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USADivision of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USADivision of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USADivision of Plastic and Reconstructive Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USAZone II flexor digitorum profundus (FDP) tendon injuries are complex, and present significant challenges in hand surgery, due to the need to balance strength and flexibility during repair. Traditional suture techniques often lead to complications such as adhesions or tendon rupture, prompting the exploration of novel strategies to improve outcomes. This review investigates the use of flexor digitorum superficialis (FDS) tendon autografts to reinforce FDP repairs, alongside the integration of biomaterials to enhance mechanical strength without sacrificing FDS tissue. Key biomaterials, including collagen–polycaprolactone (PCL) composites, are evaluated for their biocompatibility, mechanical integrity, and controlled degradation properties. Collagen-PCL emerges as a leading candidate, offering the potential to reduce adhesions and promote tendon healing. Although nanomaterials such as nanofibers and nanoparticles show promise in preventing adhesions and supporting cellular proliferation, their application remains limited by manufacturing challenges. By combining advanced repair techniques with biomaterials like collagen-PCL, this approach aims to improve surgical outcomes and minimize complications. Future research will focus on validating these findings in biological models, assessing tendon healing through imaging, and comparing the cost-effectiveness of biomaterial-enhanced repairs with traditional methods. This review underscores the potential for biomaterial-based approaches to transform FDP tendon repair.https://www.mdpi.com/2079-4983/16/3/97flexor tendon repairbiomaterials for tendon repairnanomaterials for tendon repairzone II flexor tendon repair |
| spellingShingle | Rishith R. Mereddy Emily E. Zona Camille J. LaLiberte Aaron M. Dingle Optimizing Flexor Digitorum Profundus Tendon Repair: A Narrative Review Journal of Functional Biomaterials flexor tendon repair biomaterials for tendon repair nanomaterials for tendon repair zone II flexor tendon repair |
| title | Optimizing Flexor Digitorum Profundus Tendon Repair: A Narrative Review |
| title_full | Optimizing Flexor Digitorum Profundus Tendon Repair: A Narrative Review |
| title_fullStr | Optimizing Flexor Digitorum Profundus Tendon Repair: A Narrative Review |
| title_full_unstemmed | Optimizing Flexor Digitorum Profundus Tendon Repair: A Narrative Review |
| title_short | Optimizing Flexor Digitorum Profundus Tendon Repair: A Narrative Review |
| title_sort | optimizing flexor digitorum profundus tendon repair a narrative review |
| topic | flexor tendon repair biomaterials for tendon repair nanomaterials for tendon repair zone II flexor tendon repair |
| url | https://www.mdpi.com/2079-4983/16/3/97 |
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