The potential therapeutic role of Lisinopril in augmenting the striatal neuroplasticity via the striatal ACE2/Ang1-7/MAS receptor axis in 3-nitropropionic acid-induced Huntington’s disease in rats: shifting paradigms in Huntington’s disease treatment

The potential therapeutic role of Lisinopril in augmenting the striatal neuroplasticity via the striatal ACE2/Ang1-7/MAS receptor axis in 3-nitropropionic acid-induced Huntington’s disease in rats: shifting paradigms in Huntington’s disease treatment

Abstract Background The exact pathogenesis of Huntington’s disease (HD) remains unclear. However, mitochondrial dysfunction and oxidative stress are supposed to play a significant role. The objective of this study was to examine the possible neuroprotective effect of Lisinopril (Lisino) in a 3-nitro...

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Main Authors: Hanaa Wanas, Mostafa Adel Rabie, Basma Emad Aboulhoda, Nagwa Mahmoud Ramadan, Sahar Abdelwahab, Sara Sayed Kadry Abdallah, Eid Nassar Ali, Leyan Nasruddeen Khayruddeen, Yasir Hassan Elhassan, Hadel Mahroos Alghabban, Shaimaa Mohamed Abdelsalam, Amira Karam Khalifa
Format: Article
Language:English
Published: SpringerOpen 2024-11-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Huntington’s disease
Renin–angiotensin system
Lisinopril
Mitochondrial dysfunction
3-nitropropionic acid
Online Access:https://doi.org/10.1186/s43094-024-00724-z
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