Frailty and Age-Associated Assessments Associated with Chronic Kidney Disease and Transplantation Outcomes
Background. Frailty is often defined as a decrease in physiological reserve and has been shown to be correlated with adverse health outcomes and mortality in the general population. This condition is highly prevalent in the chronic kidney disease (CKD) patient population as well as in kidney transpl...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2023/1510259 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850222368673234944 |
|---|---|
| author | Christian P. Fulinara Alina Huynh Deena Goldwater Basmah Abdalla Joanna Schaenman |
| author_facet | Christian P. Fulinara Alina Huynh Deena Goldwater Basmah Abdalla Joanna Schaenman |
| author_sort | Christian P. Fulinara |
| collection | DOAJ |
| description | Background. Frailty is often defined as a decrease in physiological reserve and has been shown to be correlated with adverse health outcomes and mortality in the general population. This condition is highly prevalent in the chronic kidney disease (CKD) patient population as well as in kidney transplant (KT) recipients. Other age-associated changes include sarcopenia, nutrition, cognition, and depression. In assessing the contributions of these components to patient outcomes and their prevalence in the CKD and KT patient population, it can be determined how such variables may be associated with frailty and the extent to which they may impact the adverse outcomes an individual may experience. Objectives. We sought to perform a systematic literature review to review published data on frailty and associated age-associated syndromes in CKD and KT patients. Results. Over 80 references pertinent to frailty, sarcopenia, nutrition, cognition, or depression in patients with CKD or KT were identified. Systematic review was performed to evaluate the data supporting the use of the following approaches: Fried Frailty, Short Physical Performance Battery, Frailty Index, Sarcopenia Index, CT scan quantification of muscle mass, health-related quality of life, and assessment tools for nutrition, cognition, and depression. Conclusion. This report represents a comprehensive review of previously published research articles on this topic. The intersectionality between all these components in contributing to the patient’s clinical status suggests a need for a multifaceted approach to developing comprehensive care and treatment for the CKD and KT population to improve outcomes before and after transplantation. |
| format | Article |
| id | doaj-art-6f44de847f7a4bf7a494d5376a2b00f4 |
| institution | OA Journals |
| issn | 2090-0015 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-6f44de847f7a4bf7a494d5376a2b00f42025-08-20T02:06:22ZengWileyJournal of Transplantation2090-00152023-01-01202310.1155/2023/1510259Frailty and Age-Associated Assessments Associated with Chronic Kidney Disease and Transplantation OutcomesChristian P. Fulinara0Alina Huynh1Deena Goldwater2Basmah Abdalla3Joanna Schaenman4Division of Infectious DiseasesDivision of Infectious DiseasesDivisions of Geriatrics and CardiologyDivision of NephrologyDivision of Infectious DiseasesBackground. Frailty is often defined as a decrease in physiological reserve and has been shown to be correlated with adverse health outcomes and mortality in the general population. This condition is highly prevalent in the chronic kidney disease (CKD) patient population as well as in kidney transplant (KT) recipients. Other age-associated changes include sarcopenia, nutrition, cognition, and depression. In assessing the contributions of these components to patient outcomes and their prevalence in the CKD and KT patient population, it can be determined how such variables may be associated with frailty and the extent to which they may impact the adverse outcomes an individual may experience. Objectives. We sought to perform a systematic literature review to review published data on frailty and associated age-associated syndromes in CKD and KT patients. Results. Over 80 references pertinent to frailty, sarcopenia, nutrition, cognition, or depression in patients with CKD or KT were identified. Systematic review was performed to evaluate the data supporting the use of the following approaches: Fried Frailty, Short Physical Performance Battery, Frailty Index, Sarcopenia Index, CT scan quantification of muscle mass, health-related quality of life, and assessment tools for nutrition, cognition, and depression. Conclusion. This report represents a comprehensive review of previously published research articles on this topic. The intersectionality between all these components in contributing to the patient’s clinical status suggests a need for a multifaceted approach to developing comprehensive care and treatment for the CKD and KT population to improve outcomes before and after transplantation.http://dx.doi.org/10.1155/2023/1510259 |
| spellingShingle | Christian P. Fulinara Alina Huynh Deena Goldwater Basmah Abdalla Joanna Schaenman Frailty and Age-Associated Assessments Associated with Chronic Kidney Disease and Transplantation Outcomes Journal of Transplantation |
| title | Frailty and Age-Associated Assessments Associated with Chronic Kidney Disease and Transplantation Outcomes |
| title_full | Frailty and Age-Associated Assessments Associated with Chronic Kidney Disease and Transplantation Outcomes |
| title_fullStr | Frailty and Age-Associated Assessments Associated with Chronic Kidney Disease and Transplantation Outcomes |
| title_full_unstemmed | Frailty and Age-Associated Assessments Associated with Chronic Kidney Disease and Transplantation Outcomes |
| title_short | Frailty and Age-Associated Assessments Associated with Chronic Kidney Disease and Transplantation Outcomes |
| title_sort | frailty and age associated assessments associated with chronic kidney disease and transplantation outcomes |
| url | http://dx.doi.org/10.1155/2023/1510259 |
| work_keys_str_mv | AT christianpfulinara frailtyandageassociatedassessmentsassociatedwithchronickidneydiseaseandtransplantationoutcomes AT alinahuynh frailtyandageassociatedassessmentsassociatedwithchronickidneydiseaseandtransplantationoutcomes AT deenagoldwater frailtyandageassociatedassessmentsassociatedwithchronickidneydiseaseandtransplantationoutcomes AT basmahabdalla frailtyandageassociatedassessmentsassociatedwithchronickidneydiseaseandtransplantationoutcomes AT joannaschaenman frailtyandageassociatedassessmentsassociatedwithchronickidneydiseaseandtransplantationoutcomes |