Estradiol and vitamin D exert a synergistic effect on preventing osteoporosis via the miR-351-5p/IRS1 axis and mTOR/NFκB signaling pathway

Estradiol and vitamin D exert a synergistic effect on preventing osteoporosis via the miR-351-5p/IRS1 axis and mTOR/NFκB signaling pathway

Abstract This study aimed to investigate the antiosteoporotic effects and regulatory mechanisms of estradiol (E2) and vitamin D. MC3T3-E1 cells were treated with E2, vitamin D, or their combination, followed by a systematic assessment of cell proliferation and osteogenic differentiation capacity acr...

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Bibliographic Details
Main Authors: Xiaoyan Dai, Changcun Liu, Wenkai Bi, Guiwen Zheng, Kuan Lv, Zhiming Xia
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Osteoporosis
Estradiol
Vitamin D
miR-351-5p
IRS1
mTOR/NFκB signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-02808-z
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