Biosafety status analysis and risk assessment of laboratories from 2021 to 2023 in Jiaxing, China
In order to understand the laboratory biosafety status of Jiaxing from 2021 to 2023, before and after the end of the COVID-19 strict control strategy, this study used Zhejiang local standard DB33/T 2540 to conduct biosafety quality control inspection and risk identification, and used Chinese industr...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1442651/full |
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| author | Yong Yan Chan Li Jingyu Xu Lei Gao Zhenggang Jiang Shencong Lv Ping Li Zelin Xiang Peiyan He Ganglin Ren Guoying Zhu Zhongwen Chen |
| author_facet | Yong Yan Chan Li Jingyu Xu Lei Gao Zhenggang Jiang Shencong Lv Ping Li Zelin Xiang Peiyan He Ganglin Ren Guoying Zhu Zhongwen Chen |
| author_sort | Yong Yan |
| collection | DOAJ |
| description | In order to understand the laboratory biosafety status of Jiaxing from 2021 to 2023, before and after the end of the COVID-19 strict control strategy, this study used Zhejiang local standard DB33/T 2540 to conduct biosafety quality control inspection and risk identification, and used Chinese industry standard RB/T 040 for risk analysis and assessment. The results showed that the major problems in biosafety management were from organization management, laboratory housekeeping, material and label management, and facilities and equipment, accounting for 39.76%, 28.97% and 14.69% respectively. Statistical analysis showed that the significant improvement of laboratory filing requirements (χ2 = 5.84, P = 0.016) was the main reason for the decrease of organization management problems (χ2 = 5.007, P = 0.025). The problems of laboratory housekeeping, experimental material and safety label management had become increasingly prominent (χ2 = 6.192, P = 0.013), especially the nonstandard use of biosafety label (χ2 = 5.218, P = 0.022). Assessment results showed that all found problems as identified risk factors in the past 3 years were determined at the level of medium or low. These suggested that in 2021–2023, the overall laboratory biosafety risk level in Jiaxing was controllable and acceptable, and the organization management had been improved greatly. At the same time, the management of laboratory housekeeping, materials and labels, especially the use of biosafety labels, had become increasingly prominent and need to be standardized and strengthened. |
| format | Article |
| id | doaj-art-6f39f097cd1f4f14bccf39595252fa5e |
| institution | OA Journals |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-6f39f097cd1f4f14bccf39595252fa5e2025-08-20T02:26:24ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-04-011310.3389/fbioe.2025.14426511442651Biosafety status analysis and risk assessment of laboratories from 2021 to 2023 in Jiaxing, ChinaYong Yan0Chan Li1Jingyu Xu2Lei Gao3Zhenggang Jiang4Shencong Lv5Ping Li6Zelin Xiang7Peiyan He8Ganglin Ren9Guoying Zhu10Zhongwen Chen11Jiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang, ChinaDepartment of Research and Emergency, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, ChinaDepartment of Microbiology, Haiyan Center for Disease Control and Prevention, Haiyan, Zhejiang, ChinaJiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang, ChinaDepartment of Research and Emergency, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, ChinaJiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang, ChinaJiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang, ChinaJiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang, ChinaJiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang, ChinaJiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang, ChinaJiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang, ChinaJiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang, ChinaIn order to understand the laboratory biosafety status of Jiaxing from 2021 to 2023, before and after the end of the COVID-19 strict control strategy, this study used Zhejiang local standard DB33/T 2540 to conduct biosafety quality control inspection and risk identification, and used Chinese industry standard RB/T 040 for risk analysis and assessment. The results showed that the major problems in biosafety management were from organization management, laboratory housekeeping, material and label management, and facilities and equipment, accounting for 39.76%, 28.97% and 14.69% respectively. Statistical analysis showed that the significant improvement of laboratory filing requirements (χ2 = 5.84, P = 0.016) was the main reason for the decrease of organization management problems (χ2 = 5.007, P = 0.025). The problems of laboratory housekeeping, experimental material and safety label management had become increasingly prominent (χ2 = 6.192, P = 0.013), especially the nonstandard use of biosafety label (χ2 = 5.218, P = 0.022). Assessment results showed that all found problems as identified risk factors in the past 3 years were determined at the level of medium or low. These suggested that in 2021–2023, the overall laboratory biosafety risk level in Jiaxing was controllable and acceptable, and the organization management had been improved greatly. At the same time, the management of laboratory housekeeping, materials and labels, especially the use of biosafety labels, had become increasingly prominent and need to be standardized and strengthened.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1442651/fullbiosafetybiosecurityrisk assessmentlaboratoryquality controlpublic health |
| spellingShingle | Yong Yan Chan Li Jingyu Xu Lei Gao Zhenggang Jiang Shencong Lv Ping Li Zelin Xiang Peiyan He Ganglin Ren Guoying Zhu Zhongwen Chen Biosafety status analysis and risk assessment of laboratories from 2021 to 2023 in Jiaxing, China Frontiers in Bioengineering and Biotechnology biosafety biosecurity risk assessment laboratory quality control public health |
| title | Biosafety status analysis and risk assessment of laboratories from 2021 to 2023 in Jiaxing, China |
| title_full | Biosafety status analysis and risk assessment of laboratories from 2021 to 2023 in Jiaxing, China |
| title_fullStr | Biosafety status analysis and risk assessment of laboratories from 2021 to 2023 in Jiaxing, China |
| title_full_unstemmed | Biosafety status analysis and risk assessment of laboratories from 2021 to 2023 in Jiaxing, China |
| title_short | Biosafety status analysis and risk assessment of laboratories from 2021 to 2023 in Jiaxing, China |
| title_sort | biosafety status analysis and risk assessment of laboratories from 2021 to 2023 in jiaxing china |
| topic | biosafety biosecurity risk assessment laboratory quality control public health |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1442651/full |
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