Corticotropin-Releasing Factor and Toll-Like Receptor Gene Expression Is Associated with Low-Grade Inflammation in Irritable Bowel Syndrome Patients with Depression
The mechanism of low-grade inflammation in irritable bowel syndrome (IBS) is unclear; our research concentrates on the involvement of the corticotropin-releasing factor (CRF) and Toll-like receptor (TLR) gene expression in the process of low-grade inflammation in IBS patients with depression. This s...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/7394924 |
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| author | Song Jizhong Wang Qiaomin Wang Chao Li Yanqing |
| author_facet | Song Jizhong Wang Qiaomin Wang Chao Li Yanqing |
| author_sort | Song Jizhong |
| collection | DOAJ |
| description | The mechanism of low-grade inflammation in irritable bowel syndrome (IBS) is unclear; our research concentrates on the involvement of the corticotropin-releasing factor (CRF) and Toll-like receptor (TLR) gene expression in the process of low-grade inflammation in IBS patients with depression. This study suggests more IBS patients are presenting with the states of depression and anxiety. IBS patients with depression have shown a lower grade inflammatory response and an imbalance of the inflammatory response. CRF1, CRF2, TLR2, and TLR4 in IBS patients with depression are significantly higher than those without depression and controls. Thus, activation of the CRF-TLR associated pathways produces an inflammatory reaction, which can concurrently affect the digestive tract and the CNS and induce the corresponding digestive and psychiatric symptoms. |
| format | Article |
| id | doaj-art-6f3669153e6e4bdc9ef0811ce778e8ff |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-6f3669153e6e4bdc9ef0811ce778e8ff2025-08-20T03:34:05ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/73949247394924Corticotropin-Releasing Factor and Toll-Like Receptor Gene Expression Is Associated with Low-Grade Inflammation in Irritable Bowel Syndrome Patients with DepressionSong Jizhong0Wang Qiaomin1Wang Chao2Li Yanqing3Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan 250012, ChinaDepartment of Gastroenterology, Anhui Provincial Hospital, Hefei 230001, ChinaDepartment of Gastroenterology, Anhui Provincial Hospital, Hefei 230001, ChinaDepartment of Gastroenterology, Qilu Hospital, Shandong University, Jinan 250012, ChinaThe mechanism of low-grade inflammation in irritable bowel syndrome (IBS) is unclear; our research concentrates on the involvement of the corticotropin-releasing factor (CRF) and Toll-like receptor (TLR) gene expression in the process of low-grade inflammation in IBS patients with depression. This study suggests more IBS patients are presenting with the states of depression and anxiety. IBS patients with depression have shown a lower grade inflammatory response and an imbalance of the inflammatory response. CRF1, CRF2, TLR2, and TLR4 in IBS patients with depression are significantly higher than those without depression and controls. Thus, activation of the CRF-TLR associated pathways produces an inflammatory reaction, which can concurrently affect the digestive tract and the CNS and induce the corresponding digestive and psychiatric symptoms.http://dx.doi.org/10.1155/2016/7394924 |
| spellingShingle | Song Jizhong Wang Qiaomin Wang Chao Li Yanqing Corticotropin-Releasing Factor and Toll-Like Receptor Gene Expression Is Associated with Low-Grade Inflammation in Irritable Bowel Syndrome Patients with Depression Gastroenterology Research and Practice |
| title | Corticotropin-Releasing Factor and Toll-Like Receptor Gene Expression Is Associated with Low-Grade Inflammation in Irritable Bowel Syndrome Patients with Depression |
| title_full | Corticotropin-Releasing Factor and Toll-Like Receptor Gene Expression Is Associated with Low-Grade Inflammation in Irritable Bowel Syndrome Patients with Depression |
| title_fullStr | Corticotropin-Releasing Factor and Toll-Like Receptor Gene Expression Is Associated with Low-Grade Inflammation in Irritable Bowel Syndrome Patients with Depression |
| title_full_unstemmed | Corticotropin-Releasing Factor and Toll-Like Receptor Gene Expression Is Associated with Low-Grade Inflammation in Irritable Bowel Syndrome Patients with Depression |
| title_short | Corticotropin-Releasing Factor and Toll-Like Receptor Gene Expression Is Associated with Low-Grade Inflammation in Irritable Bowel Syndrome Patients with Depression |
| title_sort | corticotropin releasing factor and toll like receptor gene expression is associated with low grade inflammation in irritable bowel syndrome patients with depression |
| url | http://dx.doi.org/10.1155/2016/7394924 |
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