Refractory Clostridium difficile Infection Successfully Treated with Tigecycline, Rifaximin, and Vancomycin
The occurrence of Clostridium difficile colitis is on the rise and has become more difficult to manage with standard therapy. Thus, the need for alternative treatments is essential. Tigecycline is a glycylcycline antibiotic that has been shown to be effective against C. difficile through several pub...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/702910 |
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| _version_ | 1849413483386372096 |
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| author | Dominador Lao Tom Chiang Eric Gomez |
| author_facet | Dominador Lao Tom Chiang Eric Gomez |
| author_sort | Dominador Lao |
| collection | DOAJ |
| description | The occurrence of Clostridium difficile colitis is on the rise and has become more difficult to manage with standard therapy. Thus, the need for alternative treatments is essential. Tigecycline is a glycylcycline antibiotic that has been shown to be effective against C. difficile through several published case reports and in in vitro studies. We present a case of C. difficile colitis that failed to respond to metronidazole and oral vancomycin therapy, but improved on a combination of rifaximin, tigecycline, and vancomycin. |
| format | Article |
| id | doaj-art-6f2e786a1dd8401d9cd5dc31d1e2db59 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-6f2e786a1dd8401d9cd5dc31d1e2db592025-08-20T03:34:05ZengWileyCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/702910702910Refractory Clostridium difficile Infection Successfully Treated with Tigecycline, Rifaximin, and VancomycinDominador Lao0Tom Chiang1Eric Gomez2St. Matthew’s School of Medicine, USAVeterans Affairs New Jersey Healthcare System (VA NJHCS), East Orange, NJ 07018, USADepartment of Infectious Disease, Appalachian Regional Hospital, Beckley, WV 25801, USAThe occurrence of Clostridium difficile colitis is on the rise and has become more difficult to manage with standard therapy. Thus, the need for alternative treatments is essential. Tigecycline is a glycylcycline antibiotic that has been shown to be effective against C. difficile through several published case reports and in in vitro studies. We present a case of C. difficile colitis that failed to respond to metronidazole and oral vancomycin therapy, but improved on a combination of rifaximin, tigecycline, and vancomycin.http://dx.doi.org/10.1155/2012/702910 |
| spellingShingle | Dominador Lao Tom Chiang Eric Gomez Refractory Clostridium difficile Infection Successfully Treated with Tigecycline, Rifaximin, and Vancomycin Case Reports in Medicine |
| title | Refractory Clostridium difficile Infection Successfully Treated with Tigecycline, Rifaximin, and Vancomycin |
| title_full | Refractory Clostridium difficile Infection Successfully Treated with Tigecycline, Rifaximin, and Vancomycin |
| title_fullStr | Refractory Clostridium difficile Infection Successfully Treated with Tigecycline, Rifaximin, and Vancomycin |
| title_full_unstemmed | Refractory Clostridium difficile Infection Successfully Treated with Tigecycline, Rifaximin, and Vancomycin |
| title_short | Refractory Clostridium difficile Infection Successfully Treated with Tigecycline, Rifaximin, and Vancomycin |
| title_sort | refractory clostridium difficile infection successfully treated with tigecycline rifaximin and vancomycin |
| url | http://dx.doi.org/10.1155/2012/702910 |
| work_keys_str_mv | AT dominadorlao refractoryclostridiumdifficileinfectionsuccessfullytreatedwithtigecyclinerifaximinandvancomycin AT tomchiang refractoryclostridiumdifficileinfectionsuccessfullytreatedwithtigecyclinerifaximinandvancomycin AT ericgomez refractoryclostridiumdifficileinfectionsuccessfullytreatedwithtigecyclinerifaximinandvancomycin |