Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner

Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner

Abstract Background Direct conversion of reactive glial cells to neurons is a promising avenue for neuronal replacement therapies after brain injury or neurodegeneration. The overexpression of neurogenic fate determinants in glial cells results in conversion to neurons. For repair purposes, the conv...

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Main Authors: Priya Maddhesiya, Tjasa Lepko, Andrea Steiner-Mezzardi, Julia Schneider, Veronika Schwarz, Juliane Merl-Pham, Finja Berger, Stefanie M. Hauck, Lorenza Ronfani, Marco Bianchi, Tatiana Simon, Anthodesmi Krontira, Giacomo Masserdotti, Magdalena Götz, Jovica Ninkovic
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-025-03556-z
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