Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis
Porcine infections are currently not the state-of-the-art model to study human diseases. Nevertheless, the course of human and porcine toxoplasmosis is much more comparable than that of human and murine toxoplasmosis. For example, severity of infection, transplacental transmission, and interferon-ga...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/3260289 |
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| author | Julia Nau Silvia Kathrin Eller Johannes Wenning Katrin Henrike Spekker-Bosker Horst Schroten Christian Schwerk Andrea Hotop Uwe Groß Walter Däubener |
| author_facet | Julia Nau Silvia Kathrin Eller Johannes Wenning Katrin Henrike Spekker-Bosker Horst Schroten Christian Schwerk Andrea Hotop Uwe Groß Walter Däubener |
| author_sort | Julia Nau |
| collection | DOAJ |
| description | Porcine infections are currently not the state-of-the-art model to study human diseases. Nevertheless, the course of human and porcine toxoplasmosis is much more comparable than that of human and murine toxoplasmosis. For example, severity of infection, transplacental transmission, and interferon-gamma-induced antiparasitic effector mechanisms are similar in pigs and humans. In addition, the severe immunosuppression during acute infection described in mice does not occur in the experimentally infected ones. Thus, we hypothesise that porcine Toxoplasma gondii infection data are more representative for human toxoplasmosis. We therefore suggest that the animal model chosen must be critically evaluated for its assignability to human diseases. |
| format | Article |
| id | doaj-art-6f2a02d52d47494f89545439079b0ba1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-6f2a02d52d47494f89545439079b0ba12025-02-03T01:29:53ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/32602893260289Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human ToxoplasmosisJulia Nau0Silvia Kathrin Eller1Johannes Wenning2Katrin Henrike Spekker-Bosker3Horst Schroten4Christian Schwerk5Andrea Hotop6Uwe Groß7Walter Däubener8Institute of Medical Microbiology and Hospital Hygiene, Medical Faculty, Heinrich-Heine-University Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, GermanyInstitute of Medical Microbiology and Hospital Hygiene, Medical Faculty, Heinrich-Heine-University Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, GermanyInstitute of Medical Microbiology and Hospital Hygiene, Medical Faculty, Heinrich-Heine-University Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, GermanyInstitute of Medical Microbiology and Hospital Hygiene, Medical Faculty, Heinrich-Heine-University Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, GermanyPediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, GermanyPediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, GermanyInstitute for Medical Microbiology, University Medical Center, Kreuzbergring 57, 37077 Göttingen, GermanyInstitute for Medical Microbiology, University Medical Center, Kreuzbergring 57, 37077 Göttingen, GermanyInstitute of Medical Microbiology and Hospital Hygiene, Medical Faculty, Heinrich-Heine-University Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, GermanyPorcine infections are currently not the state-of-the-art model to study human diseases. Nevertheless, the course of human and porcine toxoplasmosis is much more comparable than that of human and murine toxoplasmosis. For example, severity of infection, transplacental transmission, and interferon-gamma-induced antiparasitic effector mechanisms are similar in pigs and humans. In addition, the severe immunosuppression during acute infection described in mice does not occur in the experimentally infected ones. Thus, we hypothesise that porcine Toxoplasma gondii infection data are more representative for human toxoplasmosis. We therefore suggest that the animal model chosen must be critically evaluated for its assignability to human diseases.http://dx.doi.org/10.1155/2017/3260289 |
| spellingShingle | Julia Nau Silvia Kathrin Eller Johannes Wenning Katrin Henrike Spekker-Bosker Horst Schroten Christian Schwerk Andrea Hotop Uwe Groß Walter Däubener Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis Mediators of Inflammation |
| title | Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis |
| title_full | Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis |
| title_fullStr | Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis |
| title_full_unstemmed | Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis |
| title_short | Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis |
| title_sort | experimental porcine toxoplasma gondii infection as a representative model for human toxoplasmosis |
| url | http://dx.doi.org/10.1155/2017/3260289 |
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