Prognostic markers and molecular pathways in primary colorectal cancer with a high potential of liver metastases: a systems biology approach
Background and purpose: Colorectal cancer (CRC) holds the position of being the third most prevalent cancer and the second primary cause of cancer-related fatalities on a global scale. Approximately 65% of CRC patients survive for 5 years following diagnosis. Metastasis and recurrence frequently occ...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Research in Pharmaceutical Sciences |
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| Online Access: | https://journals.lww.com/10.4103/RPS.RPS_128_23 |
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| author | Fatemeh Bahramibanan Amir Taherkhani Rezvan Najafi Neda Alizadeh Hamidreza Ghadimipour Nastaran Barati Katayoun Derakhshandeh Meysam Soleimani |
| author_facet | Fatemeh Bahramibanan Amir Taherkhani Rezvan Najafi Neda Alizadeh Hamidreza Ghadimipour Nastaran Barati Katayoun Derakhshandeh Meysam Soleimani |
| author_sort | Fatemeh Bahramibanan |
| collection | DOAJ |
| description | Background and purpose:
Colorectal cancer (CRC) holds the position of being the third most prevalent cancer and the second primary cause of cancer-related fatalities on a global scale. Approximately 65% of CRC patients survive for 5 years following diagnosis. Metastasis and recurrence frequently occur in half of CRC patients diagnosed at the late stage. This study used bioinformatics analysis to identify key signaling pathways, hub genes, transcription factors, and protein kinases involved in transforming primary CRC with liver metastasis potential. Prognostic markers in CRC were also identified.
Experimental approach:
The GSE81582 dataset was re-analyzed to identify differentially expressed genes (DEGs) in early CRC compared to non-tumoral tissues. A protein interaction network (PIN) was constructed, revealing significant modules and hub genes. Prognostic markers, transcription factors, and protein kinases were determined. Boxplot and gene set enrichment analyses were performed.
Findings/Results:
This study identified 1113 DEGs in primary CRC compared to healthy controls. PIN analysis revealed 75 hub genes and 8 significant clusters associated with early CRC. The down-regulation of SUCLG2 and KPNA2 correlated with poor prognosis. SIN3A and CDK6 played crucial roles in early CRC transformation, affecting rRNA processing pathways.
Conclusion and implications:
This study demonstrated several pathways, biological processes, and genes mediating the malignant transformation of healthy colorectal tissues to primary CRC and may help the prognosis and treatment of patients with early CRC. |
| format | Article |
| id | doaj-art-6f261f42a49244bcbaaf4e7ba4489312 |
| institution | DOAJ |
| issn | 1735-5362 1735-9414 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Research in Pharmaceutical Sciences |
| spelling | doaj-art-6f261f42a49244bcbaaf4e7ba44893122025-08-20T03:02:10ZengWolters Kluwer Medknow PublicationsResearch in Pharmaceutical Sciences1735-53621735-94142025-01-0120112114110.4103/RPS.RPS_128_23Prognostic markers and molecular pathways in primary colorectal cancer with a high potential of liver metastases: a systems biology approachFatemeh BahramibananAmir TaherkhaniRezvan NajafiNeda AlizadehHamidreza GhadimipourNastaran BaratiKatayoun DerakhshandehMeysam SoleimaniBackground and purpose: Colorectal cancer (CRC) holds the position of being the third most prevalent cancer and the second primary cause of cancer-related fatalities on a global scale. Approximately 65% of CRC patients survive for 5 years following diagnosis. Metastasis and recurrence frequently occur in half of CRC patients diagnosed at the late stage. This study used bioinformatics analysis to identify key signaling pathways, hub genes, transcription factors, and protein kinases involved in transforming primary CRC with liver metastasis potential. Prognostic markers in CRC were also identified. Experimental approach: The GSE81582 dataset was re-analyzed to identify differentially expressed genes (DEGs) in early CRC compared to non-tumoral tissues. A protein interaction network (PIN) was constructed, revealing significant modules and hub genes. Prognostic markers, transcription factors, and protein kinases were determined. Boxplot and gene set enrichment analyses were performed. Findings/Results: This study identified 1113 DEGs in primary CRC compared to healthy controls. PIN analysis revealed 75 hub genes and 8 significant clusters associated with early CRC. The down-regulation of SUCLG2 and KPNA2 correlated with poor prognosis. SIN3A and CDK6 played crucial roles in early CRC transformation, affecting rRNA processing pathways. Conclusion and implications: This study demonstrated several pathways, biological processes, and genes mediating the malignant transformation of healthy colorectal tissues to primary CRC and may help the prognosis and treatment of patients with early CRC.https://journals.lww.com/10.4103/RPS.RPS_128_23biomarkerscancercrcpathogenesispathwayprognosis |
| spellingShingle | Fatemeh Bahramibanan Amir Taherkhani Rezvan Najafi Neda Alizadeh Hamidreza Ghadimipour Nastaran Barati Katayoun Derakhshandeh Meysam Soleimani Prognostic markers and molecular pathways in primary colorectal cancer with a high potential of liver metastases: a systems biology approach Research in Pharmaceutical Sciences biomarkers cancer crc pathogenesis pathway prognosis |
| title | Prognostic markers and molecular pathways in primary colorectal cancer with a high potential of liver metastases: a systems biology approach |
| title_full | Prognostic markers and molecular pathways in primary colorectal cancer with a high potential of liver metastases: a systems biology approach |
| title_fullStr | Prognostic markers and molecular pathways in primary colorectal cancer with a high potential of liver metastases: a systems biology approach |
| title_full_unstemmed | Prognostic markers and molecular pathways in primary colorectal cancer with a high potential of liver metastases: a systems biology approach |
| title_short | Prognostic markers and molecular pathways in primary colorectal cancer with a high potential of liver metastases: a systems biology approach |
| title_sort | prognostic markers and molecular pathways in primary colorectal cancer with a high potential of liver metastases a systems biology approach |
| topic | biomarkers cancer crc pathogenesis pathway prognosis |
| url | https://journals.lww.com/10.4103/RPS.RPS_128_23 |
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