Synergistic potential of CDH3 in targeting CRC metastasis and enhancing immunotherapy

Synergistic potential of CDH3 in targeting CRC metastasis and enhancing immunotherapy

Abstract Background Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, particularly due to advanced-stage metastasis. P-cadherin (CDH3), a potential therapeutic target, is highly expressed in CRC tissues and associated with poor prognosis and metastasis. However, the mechan...

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Bibliographic Details
Main Authors: Chen Fu, Jia Fu, Chaoyue Liu, Zhaojin Yu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Cancer
Subjects:
CDH3
Colon cancer
Immune
Prognosis
EMT
Drug target
Online Access:https://doi.org/10.1186/s12885-025-13845-2
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