Global sensitivity analysis of Open Systems Pharmacology Suite physiologically based pharmacokinetic models

Global sensitivity analysis of Open Systems Pharmacology Suite physiologically based pharmacokinetic models

Abstract Sensitivity analyses are important components of physiologically based pharmacokinetic (PBPK) model development and are required by regulatory agencies for PBPK submissions. They assess the impact of parametric uncertainty and variability on model estimates, aid model optimization by identi...

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Bibliographic Details
Main Authors: Abdulkarim Najjar, Abdullah Hamadeh, Sophia Krause, Andreas Schepky, Andrea Edginton
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.13256
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