CBX4 regulation of senescence and associated diseases: Molecular pathways and mechanisms
Polycomb repressive complex 1 (PRC1) is a multisubunit, evolutionarily conserved epigenetic regulator critical to numerous biological processes. Being a core component of the canonical PRC1 subunit within the Polycomb group protein complex, Chromobox4 (CBX4), a SUMO E3 ligase, can bind to H3K27me3 a...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825001306 |
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| author | Qianxing Hu Linming Su Wanli Zhao Yinuo Jin Liang Jin Yue Yang Fangfang Zhang |
| author_facet | Qianxing Hu Linming Su Wanli Zhao Yinuo Jin Liang Jin Yue Yang Fangfang Zhang |
| author_sort | Qianxing Hu |
| collection | DOAJ |
| description | Polycomb repressive complex 1 (PRC1) is a multisubunit, evolutionarily conserved epigenetic regulator critical to numerous biological processes. Being a core component of the canonical PRC1 subunit within the Polycomb group protein complex, Chromobox4 (CBX4), a SUMO E3 ligase, can bind to H3K27me3 and recruit PRC1. This ligase regulates the SUMOylation of various proteins and permits their post-translational modification under different physiological conditions. CBX4 has been reported to regulate the development of senescence and various diseases in vivo. This review delves into the physiological functions and action mechanisms of CBX4 across different tissues and cells, particularly focusing on its primarily roles in migration, cellular senescence, metabolic dysregulation, inflammation development, and tumor proliferation. Targeting CBX4 offers a therapeutic potential for delaying cell senescence and suppressing tumor growth. |
| format | Article |
| id | doaj-art-6f022fae84f74b4d8057a9ff780d1cd3 |
| institution | OA Journals |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-6f022fae84f74b4d8057a9ff780d1cd32025-08-20T02:18:55ZengElsevierPharmacological Research1096-11862025-05-0121510770510.1016/j.phrs.2025.107705CBX4 regulation of senescence and associated diseases: Molecular pathways and mechanismsQianxing Hu0Linming Su1Wanli Zhao2Yinuo Jin3Liang Jin4Yue Yang5Fangfang Zhang6State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of life Science and Technology, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, ChinaState Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of life Science and Technology, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, ChinaInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Mem. Sun Yat-Sen), Nanjing, ChinaNanjing HanKai Academy, Jiangpu Street, Pukou District, Nanjing, ChinaState Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of life Science and Technology, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, China; Corresponding authors.State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of life Science and Technology, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, China; Corresponding authors.State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of life Science and Technology, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, China; Corresponding authors.Polycomb repressive complex 1 (PRC1) is a multisubunit, evolutionarily conserved epigenetic regulator critical to numerous biological processes. Being a core component of the canonical PRC1 subunit within the Polycomb group protein complex, Chromobox4 (CBX4), a SUMO E3 ligase, can bind to H3K27me3 and recruit PRC1. This ligase regulates the SUMOylation of various proteins and permits their post-translational modification under different physiological conditions. CBX4 has been reported to regulate the development of senescence and various diseases in vivo. This review delves into the physiological functions and action mechanisms of CBX4 across different tissues and cells, particularly focusing on its primarily roles in migration, cellular senescence, metabolic dysregulation, inflammation development, and tumor proliferation. Targeting CBX4 offers a therapeutic potential for delaying cell senescence and suppressing tumor growth.http://www.sciencedirect.com/science/article/pii/S1043661825001306Chromobox4SumoylationPolycomb Repressive Complex 1Cellular senescenceTumorigenesis |
| spellingShingle | Qianxing Hu Linming Su Wanli Zhao Yinuo Jin Liang Jin Yue Yang Fangfang Zhang CBX4 regulation of senescence and associated diseases: Molecular pathways and mechanisms Pharmacological Research Chromobox4 Sumoylation Polycomb Repressive Complex 1 Cellular senescence Tumorigenesis |
| title | CBX4 regulation of senescence and associated diseases: Molecular pathways and mechanisms |
| title_full | CBX4 regulation of senescence and associated diseases: Molecular pathways and mechanisms |
| title_fullStr | CBX4 regulation of senescence and associated diseases: Molecular pathways and mechanisms |
| title_full_unstemmed | CBX4 regulation of senescence and associated diseases: Molecular pathways and mechanisms |
| title_short | CBX4 regulation of senescence and associated diseases: Molecular pathways and mechanisms |
| title_sort | cbx4 regulation of senescence and associated diseases molecular pathways and mechanisms |
| topic | Chromobox4 Sumoylation Polycomb Repressive Complex 1 Cellular senescence Tumorigenesis |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825001306 |
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