4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain

4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain

Purpose: To investigate the pathological changes of the synovium in mice with post-traumatic osteoarthritis (PTOA) treated with 4-octyl itaconate (4-OI) and evaluate the therapeutic effects of 4-OI. Methods: In the phenotypic validation experiment, the mice were randomly divided into 3 groups: wild-...

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Bibliographic Details
Main Authors: Yu-Zhen Tang, Wan Chen, Bao-Yun Xu, Gang He, Xiu-Cheng Fan, Kang-Lai Tang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Chinese Journal of Traumatology
Subjects:
4-Octyl itaconate
Synovitis
Post-traumatic osteoarthritis
Pain
Online Access:http://www.sciencedirect.com/science/article/pii/S1008127524001548
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